TNF Receptor 2 and Disease: Autoimmunity and Regenerative Medicine.
TNF Receptor 2 and Disease: Autoimmunity and Regenerative Medicine.
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TNF受体2和疾病：自身免疫性和再生医学。
DOI：
10.3389/fimmu.2013.00478
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发表时间：
2013-12-23
影响因子：
7.3
通讯作者：
Davis M
中科院分区：
文献类型：
--
作者：
Faustman DL;Davis M
调节性细胞因子肿瘤坏死因子通过两种受体：TNFR1和TNFR2发挥作用。在多种自身免疫性疾病中，TNFR2信号的缺陷是显而易见的。自身免疫性疾病的一种新的治疗策略是通过给予肿瘤坏死因子、肿瘤坏死因子诱导剂或TNFR2激动剂选择性地破坏自身反应性T细胞。一种相关的策略是依赖TNFR2激动剂来诱导抑制细胞毒性T细胞的T调节细胞(Tregs)。作为一种治疗策略，靶向TNFR2可能优于TNFR1，因为它在T细胞、神经元亚群和其他一些细胞类型上的细胞分布更有限，而TNFR1在全身表达。本文综述了TNFR2的表达、结构和信号转导；自身免疫病中的TNFR2信号转导；自身免疫中针对TNFR2的治疗策略；以及TNFR2促进终末器官再生的潜力。
The regulatory cytokine tumor necrosis factor (TNF) exerts its effects through two receptors: TNFR1 and TNFR2. Defects in TNFR2 signaling are evident in a variety of autoimmune diseases. One new treatment strategy for autoimmune disease is selective destruction of autoreactive T cells by administration of TNF, TNF inducers, or TNFR2 agonism. A related strategy is to rely on TNFR2 agonism to induce T-regulatory cells (Tregs) that suppress cytotoxic T cells. Targeting TNFR2 as a treatment strategy is likely superior to TNFR1 because of its more limited cellular distribution on T cells, subsets of neurons, and a few other cell types, whereas TNFR1 is expressed throughout the body. This review focuses on TNFR2 expression, structure, and signaling; TNFR2 signaling in autoimmune disease; treatment strategies targeting TNFR2 in autoimmunity; and the potential for TNFR2 to facilitate end organ regeneration.