Regulation of Leishmania populations within the host. III. Mapping of the locus controlling susceptibility to visceral leishmaniasis in the mouse.
Regulation of Leishmania populations within the host. III. Mapping of the locus controlling susceptibility to visceral leishmaniasis in the mouse.
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宿主内利什曼原虫种群的调节。
DOI：
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发表时间：
1979
影响因子：
4.6
通讯作者：
J. Freeman
中科院分区：
文献类型：
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作者：
D. Bradley;B. Taylor;J. Blackwell;E. P. Evans;J. Freeman
小鼠对杜氏利什曼原虫的急性易感性在很大程度上是由一个名为LSH的基因座决定的。利用几组重组近交系检测到LSH基因座与1号染色体标记ID-1之间的连锁。利用同工酶和细胞遗传学标记，在回交世代中证实了1号染色体的连锁。结果表明，该基因序列为着丝粒-LSH-ID-1-ln-Dip-1。估计LSH和ID-1之间的重组频率为0.12+/-0.04。这一图谱与已知的组织亲和性基因座无关。
Acute susceptibility of the mouse to Leishmania donovani is largely determined by a single locus designated Lsh. Linkage between the Lsh locus and the Chromosome 1 marker Id-1 was detected using several sets of recombinant inbred strains. Chromosome 1 linkage was confirmed in backcross generations using isoenzymes and a cytogenetic marker. The data indicate that the gene order is centromere-Lsh-Id-1-ln-Dip-1. The estimated recombination frequency between Lsh and Id-1 is 0.12 +/- 0.04. This mapping is away from the known histocompatibility loci.