Fiber type and citrate synthase activity in the human gastrocnemius and vastus lateralis with aging
Fiber type and citrate synthase activity in the human gastrocnemius and vastus lateralis with aging
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DOI：
10.1152/jappl.1998.85.4.1337
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发表时间：
1998-10-01
影响因子：
3.3
通讯作者：
Alshami, A
中科院分区：
文献类型：
--
作者：
Houmard, JA;Weidner, ML;Alshami, A
The purpose of this study was to determine whether enzymatic and histochemical characteristics of human skeletal muscle are altered with aging. Tissues from the vastus lateralis (VL) and gastrocnemius were analyzed for citrate synthase (CS) activity and fiber type in 55 sedentary men (age range 18-80 yr). In this population, CS activity in the gastrocnemius was negatively related to age (r = -0.32, P < 0.05); there was no relationship in the VL. Treadmill-determined maximal oxygen consumption was positively related (r = 0.40, P < 0.05) to CS in the gastrocnemius but not in the VL. CS activity in the gastrocnemius was 24% lower in the oldest (greater than or equal to 60 yr, n = 10) vs. the youngest (less than or equal to 30 yr; n = 12) men; there was no change in CS activity in the VL with aging. No changes in fiber type were evident with age in either muscle. These data suggest a reduction in oxidative enzyme activity in human skeletal muscle with the aging process; this relationship may be muscle-group specific.
