MR IMAGING OF WHITE MATTER LESIONS IN UNCOMPLICATED CHRONIC-ALCOHOLISM
MR IMAGING OF WHITE MATTER LESIONS IN UNCOMPLICATED CHRONIC-ALCOHOLISM
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DOI：
10.1097/00004728-198905000-00004
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发表时间：
1989-05-01
影响因子：
1.3
通讯作者：
PASSARIELLO, R
中科院分区：
文献类型：
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作者：
GALLUCCI, M;AMICARELLI, I;PASSARIELLO, R
慢性酗酒者可能患有中枢神经系统病变，如微血管炎或神经胶质、神经和髓磷脂变性，正如对患有韦尼克脑病、胼胝体变性或脑桥中央髓鞘溶解症的受试者进行的尸检研究中所记录的那样。没有酒精中毒神经系统并发症的患者也可能会出现早期白质疾病。通过磁共振 (MR) 成像对 35 名慢性酗酒者（《诊断与统计手册 III》标准）和 35 名正常对照受试者进行了研究。排除年龄 > 60 岁、中枢神经系统受累或临床明显全身性疾病的受试者。在其余无症状的酗酒者中，除了非特异性皮质下皮质和小脑萎缩外，MR 在 14 名患者的白质中检测到多个圆形高信号区域。没有一个正常对照受试者表现出这样的发现。这些结果表明无症状酗酒患者的大脑早期受累。
Chronic alcoholics may have CNS lesions, such as microvasculitis or glial, neural, and myelin degeneration, as documented in postmortem studies on subjects who had Wernicke encephalopathy, corpus callosum degeneration, or central pontine myelinolysis. One may also expect the presence of early white matter disease in patients who do not have neurologic complications of alcoholism. Thirty-five chronic alcoholics (Diagnostic and Statistical Manual III criteria) and 35 normal control subjects were studied by means of magnetic resonance (MR) imaging. Subjects > 60 years old, or those with CNS involvement, or clinically evident systemic disorders were excluded. Of the remaining asymptomatic alcoholics, MR detected multiple round hyperintense areas in the white matter of 14 patients, in addition to aspecific corticosubcortical and cerebellar atrophies. None of the normal control subjects showed such a finding. These results suggest an early involvement of the brain in asymptomatic alcoholic patients.