Parental exposure to polycyclic aromatic hydrocarbons and the risk of childhood brain tumors - The SEARCH International Childhood Brain Tumor Study
Parental exposure to polycyclic aromatic hydrocarbons and the risk of childhood brain tumors - The SEARCH International Childhood Brain Tumor Study
复制标题
DOI：
10.1093/aje/kwh154
复制
发表时间：
2004-06-15
影响因子：
5
通讯作者：
Arslan, A
中科院分区：
文献类型：
--
作者：
Cordier, S;Monfort, C;Arslan, A
实验证据表明，父母主要通过烟草烟雾、职业接触和空气污染接触多环芳烃（PAH），可能会增加儿童时期患癌症的风险。作为SEARCH计划的一部分，在7个国家开展了以人群为基础的病例对照研究，比较了1218例儿童脑肿瘤病例和2223例对照（1976-1994）的数据。用工作暴露矩阵估计出生前5年期间父母对多环芳烃的职业暴露。风险评估根据儿童的年龄、性别和研究中心进行调整。父亲产前职业暴露于多环芳烃与所有儿童脑肿瘤（比值比(OR) = 1.3, 95%可信区间：1.1,1.6）和星形胶质细胞肿瘤（OR = 1.4, 95%可信区间：1.1,1.7）的风险增加相关。然而，没有预测暴露水平增加风险的趋势。与不吸烟、无职业暴露的父亲相比，父亲单独吸烟（OR = 1.4）也与星形胶质细胞肿瘤的风险相关。父亲职业暴露的风险较高，吸烟（OR = 1.6）或不吸烟（OR = 1.7）。孕妇在受孕前或怀孕期间职业性接触多环芳烃的情况很少见，而且这种接触与任何类型的儿童脑肿瘤都没有关系。这项大型研究支持了父亲在怀孕前接触多环芳烃会增加人类患脑肿瘤风险的假设。
Experimental evidence suggests that parental exposure to polycyclic aromatic hydrocarbons (PAH), which occurs primarily through tobacco smoke, occupational exposure, and air pollution, could increase the risk of cancer during childhood. Population-based case-control studies carried out in seven countries as part of the SEARCH Program compared data for 1,218 cases of childhood brain tumors and 2,223 controls (1976-1994). Parental occupational exposure to PAH during the 5-year period before birth was estimated with a job exposure matrix. Risk estimates were adjusted for child's age, sex, and study center. Paternal preconceptional occupational exposure to PAH was associated with increased risks of all childhood brain tumors (odds ratio (OR) = 1.3, 95% confidence interval: 1.1, 1.6) and astroglial tumors (OR = 1.4, 95% confidence interval: 1.1, 1.7). However, there was no trend of increasing risk with predicted level of exposure. Paternal smoking alone (OR = 1.4) was also associated with the risk of astroglial tumors in comparison with nonsmoking, non-occupationally-exposed fathers. Risks for paternal occupational exposure were higher, with (OR = 1.6) or without (OR = 1.7) smoking. Maternal occupational exposure to PAH before conception or during pregnancy was rare, and this exposure was not associated with any type of childhood brain tumor. This large study supports the hypothesis that paternal preconceptional exposure to PAH increases the risk of brain tumors in humans.