Haemoglobin mass and running time trial performance after recombinant human erythropoietin administration in trained men.
Haemoglobin mass and running time trial performance after recombinant human erythropoietin administration in trained men.
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DOI：
10.1371/journal.pone.0056151
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Pitsiladis YP
中科院分区：
文献类型：
--
作者：
Durussel J;Daskalaki E;Anderson M;Chatterji T;Wondimu DH;Padmanabhan N;Patel RK;McClure JD;Pitsiladis YP
Recombinant human erythropoietin (rHuEpo) increases haemoglobin mass (Hbmass) and maximal oxygen uptake ( O2 max). This study defined the time course of changes in Hbmass, O2 max as well as running time trial performance following 4 weeks of rHuEpo administration to determine whether the laboratory observations would translate into actual improvements in running performance in the field. 19 trained men received rHuEpo injections of 50 IU•kg−1 body mass every two days for 4 weeks. Hbmass was determined weekly using the optimized carbon monoxide rebreathing method until 4 weeks after administration. O2 max and 3,000 m time trial performance were measured pre, post administration and at the end of the study. Relative to baseline, running performance significantly improved by ∼6% after administration (10∶30±1∶07 min:sec vs. 11∶08±1∶15 min:sec, p<0.001) and remained significantly enhanced by ∼3% 4 weeks after administration (10∶46±1∶13 min:sec, p<0.001), while O2 max was also significantly increased post administration (60.7±5.8 mL•min−1•kg−1 vs. 56.0±6.2 mL•min−1•kg−1, p<0.001) and remained significantly increased 4 weeks after rHuEpo (58.0±5.6 mL•min−1•kg−1, p = 0.021). Hbmass was significantly increased at the end of administration compared to baseline (15.2±1.5 g•kg−1 vs. 12.7±1.2 g•kg−1, p<0.001). The rate of decrease in Hbmass toward baseline values post rHuEpo was similar to that of the increase during administration (−0.53 g•kg−1•wk−1, 95% confidence interval (CI) (−0.68, −0.38) vs. 0.54 g•kg−1•wk−1, CI (0.46, 0.63)) but Hbmass was still significantly elevated 4 weeks after administration compared to baseline (13.7±1.1 g•kg−1, p<0.001). Running performance was improved following 4 weeks of rHuEpo and remained elevated 4 weeks after administration compared to baseline. These field performance effects coincided with rHuEpo-induced elevated O2 max and Hbmass.
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影响因子：
3.2
作者：
Ehrenreich, Hannelore;Bartels, Claudia;Krampe, Henning
通讯作者：
Krampe, Henning
影响因子：
120.7
作者：
BRIEN, AJ;SIMON, TL
通讯作者：
SIMON, TL
DOI：
10.1097/00005768-200007000-00009
发表时间：
2000-07-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Birkeland, KI;Stray-Gundersen, J;Bahr, R
通讯作者：
Bahr, R
DOI：
10.1249/01.mss.0000039306.92778.df
发表时间：
2002-12-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Lucía, A;Hoyos, J;Chicharro, JL
通讯作者：
Chicharro, JL
影响因子：
11.1
作者：
BERGLUND, B;EKBLOM, B
通讯作者：
EKBLOM, B