Chromosomally integrated HHV-6: impact on virus, cell and organismal biology
Chromosomally integrated HHV-6: impact on virus, cell and organismal biology
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DOI：
10.1016/j.coviro.2014.09.010
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发表时间：
2014-12-01
影响因子：
5.9
通讯作者：
Flamand, Louis
中科院分区：
文献类型：
--
作者：
Kaufer, Benedikt B.;Flamand, Louis
HHV-6将其基因组整合到人类染色体的端粒中。整合可以发生在体细胞或配子中，后者导致每个细胞中都有HHV-6基因组的个体。这种情况会传播给后代，并被称为遗传性染色体整合人类疱疹病毒6型(iciHHV-6)。虽然整合可以发生在不同的染色体上，但它总是发生在端粒区。这种整合机制代表了一种在潜伏期内保持病毒基因组的方法，这在人类疱疹病毒中是独一无二的。最近的工作提供了证据，证明整合的HHV-6基因组可以从宿主染色体上动员起来，导致疾病的发生。详细讨论了iciHHV-6所需的结构决定因素、假定的整合机制以及生物学和医学后果。
HHV-6 integrates its genome into telomeres of human chromosomes. Integration can occur in somatic cells or gametes, the latter leading to individuals harboring the HHV-6 genome in every cell. This condition is transmitted to descendants and referred to as inherited chromosomally integrated human herpesvirus 6 (iciHHV-6). Although integration can occur in different chromosomes, it invariably takes place in the telomere region. This integration mechanism represents a way to maintain the virus genome during latency, which is so far unique amongst human herpesviruses. Recent work provides evidence that the integrated HHV-6 genome can be mobilized from the host chromosome, resulting in the onset of disease. Details on required structural determinants, putative integration mechanisms and biological and medical consequences of iciHHV-6 are discussed.