Chronic cutaneous lupus erythematosus in vitiligo.
Chronic cutaneous lupus erythematosus in vitiligo.
复制标题
慢性皮肤红斑狼疮白癜风。
作者：
Hillary Johnson;N. Bossenbroek;Karla S. Rosenman;S. Meehan;Mirin Robles;M. Pomeranz
一位49岁女性，在阳光暴露的皮肤上出现7年的皮炎、湿疹、鳞屑斑块，仅局限于先前存在的脱色斑块。组织学检查显示符合皮肤红斑狼疮伴苔藓样特征的改变，并证实为连续性白癜风。局限于白癜风区域的慢性皮肤红斑狼疮的诊断取决于临床病理相关性，并可能反映自身免疫素质。因此，开始羟氯喹和局部糖皮质激素治疗，报告瘙痒、红斑和鳞屑改善。临床监测鳞状细胞癌的发展，在慢性炎症和阳光照射的地区是必要的。
A 49-year-old woman presented with a seven-year history of pruritic, erythematous, scaling plaques on sun-exposed skin that localized only to pre-existing depigmented patches. Histopathologic examination showed changes consistent with cutaneous lupus erythematosus with lichenoid features and confirmed contiguous vitiligo. Diagnosis of chronic cutaneous lupus erythematosus localized to areas of vitiligo was determined by clinicopathologic correlation and may reflect an autoimmune diathesis. Consequently, hydroxychloroquine and topical glucocorticoids therapy were initiated with reported improvement in pruritus, erythema, and scale. Clinical monitoring for development of squamous-cell carcinoma in areas of chronic inflammation and sun-exposure is imperative.