Serum and Synovial Fluid Interleukin-6 for the Diagnosis of Periprosthetic Joint Infection.
Serum and Synovial Fluid Interleukin-6 for the Diagnosis of Periprosthetic Joint Infection.
复制标题
血清和滑液 IL-6 用于诊断假体周围感染
DOI：
10.1038/s41598-017-01713-4
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发表时间：
2017-05-04
影响因子：
4.6
通讯作者：
Yan M
中科院分区：
文献类型：
--
作者：
Xie K;Dai K;Qu X;Yan M
诊断假体周围关节感染（PJI）的金标准尚未建立。本研究的目的是评价血清和滑液白细胞介素-6水平对PJI的诊断价值。检索MEDLINE和EMBASE数据库，检索1990年1月至2016年10月期间发表的描述使用血清和滑液IL-6诊断PJI的研究。17项研究被纳入分析。血清和滑液IL-6的总敏感性分别为0.72（95%可信区间[CI]: 0.63-0.80）和0.91 （95% CI: 0.82-0.96）。血清和滑液IL-6的合并特异性分别为0.89 （95% CI: 0.77-0.95）和0.90 （95% CI: 0.84-0.95）。血清和滑液IL-6的合并诊断优势比（DORs）分别为20 （95% CI: 7-58）和101 (95% CI: 28-358)，合并曲线下面积（auc）分别为0.83 （95% CI: 0.79-0.86）和0.96 （95% CI: 0.94-0.98）。滑液IL-6对PJI有较高的诊断价值。虽然血清IL-6检测的敏感性低于滑液IL-6检测，但由于其高特异性，可作为义肢失败患者的常规处方。
A gold standard for diagnosis of periprosthetic joint infection (PJI) has not yet been established. The objective of this study was to evaluate the diagnostic value of serum and synovial fluid interleukin (IL)-6 levels for PJI. The MEDLINE and EMBASE databases were searched for studies describing PJI diagnosis using serum and synovial fluid IL-6 and published between January 1990 and October 2016. Seventeen studies were included in the analysis. The pooled sensitivities of serum and synovial fluid IL-6 were 0.72 (95% confidence interval [CI]: 0.63–0.80) and 0.91 (95% CI: 0.82–0.96), respectively. The pooled specificities of serum and synovial fluid IL-6 were 0.89 (95% CI: 0.77–0.95) and 0.90 (95% CI: 0.84–0.95), respectively. The pooled diagnostic odds ratios (DORs) of serum and synovial fluid IL-6 were 20 (95% CI: 7–58) and 101 (95% CI: 28–358), respectively, and the pooled areas under the curve (AUCs) were 0.83 (95% CI: 0.79–0.86) and 0.96 (95% CI: 0.94–0.98), respectively. Synovial fluid IL-6 had high diagnostic value for PJI. Although serum IL-6 test was less sensitive than synovial fluid IL-6 test, it may be regularly prescribed for patients with prosthetic failure owing to its high specificity.