Does participation in leisure activities lead to reduced risk of Alzheimer's disease? A prospective study of Swedish twins
Does participation in leisure activities lead to reduced risk of Alzheimer's disease? A prospective study of Swedish twins
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DOI：
10.1093/geronb/58.5.p249
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发表时间：
2003-09-01
影响因子：
6.2
通讯作者：
Gatz, M
中科院分区：
文献类型：
--
作者：
Crowe, M;Andel, R;Gatz, M
这项研究调查了在成年早期和中期参与休闲活动是否与降低阿尔茨海默病的风险有关。样本包括107对痴呆症不一致的同性双胞胎，他们在临床评估前20多年自我报告了休闲活动的信息。这些活动的因素分析产生了三个活动因素：知识文化，自我提高，和国内活动。配对分析比较了不一致双胞胎的活动，同时控制了教育水平。对于总样本，参与更多的休闲活动与阿尔茨海默病和痴呆症的风险降低有关。更多地参与智力文化活动与女性患阿尔茨海默病的风险较低有关，尽管男性并非如此。
This study examined whether participation in leisure activities during early and middle adulthood was associated with reduced risk of Alzheimer's disease. The sample consisted of 107 same-sex twin pairs discordant for dementia and for whom information on leisure activities was self-reported more than 20 years prior to clinical evaluation. A factor analysis of these activities yielded three activity factors: intellectual-cultural, self-improvement, and domestic activity. Matched-pair analyses compared activities within the discordant twin pairs while controlling for level of education. For the total sample, participation in a greater overall number of leisure activities was associated with lower risk of both Alzheimer's disease and dementia in general. Greater participation in intellectual-cultural activities was associated with lower risk of Alzheimer's disease for women, although not for men.