ALZHEIMERS-DISEASE - BETA-AMYLOID PRECURSOR PROTEIN MESSENGER-RNA EXPRESSION IN MONONUCLEAR BLOOD-CELLS
ALZHEIMERS-DISEASE - BETA-AMYLOID PRECURSOR PROTEIN MESSENGER-RNA EXPRESSION IN MONONUCLEAR BLOOD-CELLS
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DOI：
10.1016/0304-3940(91)90445-y
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发表时间：
1991-10-28
影响因子：
2.5
通讯作者：
TINKLENBERG, JR
中科院分区：
文献类型：
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作者：
ALLEN, JS;MURPHY, GM;TINKLENBERG, JR
对阿尔茨海默病、唐氏综合症和对照受试者的外周单核血细胞 (PMBC) 中的 β-淀粉样蛋白前体蛋白 (β-APP) mRNA 进行了检查。 PMBC 的总 RNA 被逆转录，然后使用聚合酶链式反应 (PCR) 进行扩增。 3 个主要的 β-APP 转录物在所有受试者的 PMBC 中都有表达。结果表明，PMBCS 可能是大脑和外周组织中异常淀粉样蛋白沉积的循环来源。
Beta-amyloid precursor protein (beta-APP) mRNA was examined in peripheral mononuclear blood cells (PMBCs) in Alzheimer's disease, Down's syndrome and control subjects. Total RNA from PMBCs was reverse transcribed and then amplified using the polymerase chain reaction (PCR). The 3 major beta-APP transcripts were expressed in PMBCs from all subjects. The results suggest that PMBCS could be a circulating source for abnormal amyloid deposition in the brain and in peripheral tissues.