Assessment of the antibacterial activity of selected flavonoids and consideration of discrepancies between previous reports
Assessment of the antibacterial activity of selected flavonoids and consideration of discrepancies between previous reports
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DOI：
10.1078/0944-5013-00206
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发表时间：
2003-01-01
影响因子：
6.7
通讯作者：
Lamb, AJ
中科院分区：
文献类型：
--
作者：
Cushnie, TPT;Hamilton, VES;Lamb, AJ
芹菜素、黄芩苷和高良姜素对金黄色葡萄球菌、粪肠球菌、大肠杆菌等敏感菌株和耐药菌株的抗菌活性。粪肠球菌、大肠埃希菌和铜绿假单胞菌。使用琼脂稀释试验，高良姜素显示对所有六种S.金黄色葡萄球菌，但对其他物种的活性可忽略不计。芹菜素对S.金黄色葡萄球菌，黄芩苷没有检测到活性。在抑制曲线研究中，高良姜素导致生长中的S.金黄色葡萄球菌NCTC 6571。S.还观察到金黄色葡萄球菌NCTC 11561和NCMB 9968群体。
Activity of the flavonoids apigenin, baicalin and galangin against sensitive and antibiotic resistant strains of Staphylococcus aureus, Enterococcus faecalis, E. faecium, Escherichia coli and Pseudomonas aeruginosa was investigated. Using an agar dilution assay, galangin was shown to have a minimum inhibitory concentration (MIC) of 25 to 50 mug/mL against all six strains of S. aureus but negligible activity against the other species. Apigenin displayed only marginal activity against S. aureus and no activity was detected from baicalin. In inhibition curve studies, galangin caused a 100,000-fold decrease in the viability of a growing population of S. aureus NCTC 6571 within the first two hours of treatment. Decreases in viability of S. aureus NCTC 11561 and NCIMB 9968 populations were also observed.