Replication of loci influencing ages at menarche and menopause in Hispanic women: the Womens Health Initiative SHARe Study
Replication of loci influencing ages at menarche and menopause in Hispanic women: the Womens Health Initiative SHARe Study
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DOI：
10.1093/hmg/ddr570
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发表时间：
2012-03-15
影响因子：
3.5
通讯作者：
Franceschini, Nora
中科院分区：
文献类型：
--
作者：
Chen, Christina T. L.;Fernandez-Rhodes, Lindsay;Franceschini, Nora
一些全基因组研究已经确定了与欧洲血统女性的生殖特征相关的基因座，如初潮和绝经年龄。在这项研究中，我们调查了这些位点的相关性，在少数民族美国西班牙裔妇女。我们利用了3468名接受基因分型的女性的数据，作为女性健康倡议SNP健康协会资源的一部分。我们复制了8个位点（LRP 18、LIN 28 B、CENPW、INHBA、TMEM 38 B、ZNF 483、NFAT 5和OLFM 2）与初潮年龄的关联，以及2个位点（MCM 8和BRSK 1/TMEM 150 B）与绝经年龄的关联。MCM 8位点也与绝经早期风险相关。3个基因座（CENPW、MCM 8和BRSK 1/TMEM 150 B）与生殖寿命相关。我们提供的证据表明，在欧洲人群中发现的影响生殖特征的遗传变异在美国少数民族西班牙裔妇女中也很重要。
Several genome-wide studies have identified loci associated with reproductive traits, such as ages of menarche and menopause, in women of European ancestry. In this study, we investigated the relevance of these loci in minority US Hispanic women. We utilized data from 3468 women who were genotyped as a part of the Womens Health Initiative SNP Health Association Resource. We replicated associations of eight loci (LRP18, LIN28B, CENPW, INHBA, TMEM38B, ZNF483, NFAT5 and OLFM2) with age at menarche, and of two loci (MCM8 and BRSK1/TMEM150B) with age at menopause. The MCM8 locus was also associated with early menopause risk. Three loci (CENPW, MCM8 and BRSK1/TMEM150B) were associated with the length of reproductive lifespan. We provide evidence that genetic variants influencing reproductive traits identified in European populations are also important in minority US Hispanic women.