Cichorium intybus from Eastern Anatolia: Phenolic composition, antioxidant and enzyme inhibitory activities
Cichorium intybus from Eastern Anatolia: Phenolic composition, antioxidant and enzyme inhibitory activities
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DOI：
10.1016/j.indcrop.2014.05.043
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发表时间：
2014-09-01
影响因子：
5.9
通讯作者：
Konczak, Izabela
中科院分区：
文献类型：
--
作者：
Dalar, Abdullah;Konczak, Izabela
在土耳其安纳托利亚东部地区，由菊苣制成的凉茶或汤剂是广泛使用的传统草药之一，用于治疗糖尿病、癫痫、痔疮、炎症和消化系统疾病。安纳托利亚东部种植的 C intybus 植物的粗亲水提取物的抗氧化能力可与许多常见药用和中药植物相媲美，其叶子表现出卓越的抗氧化潜力。从叶子中获得的冻干亲水提取物，包含羟基肉桂酸和黄酮类化合物，其中主要化合物为绿原酸、咖啡果酸、菊苣酸和木犀草素己糖苷的异构体。该提取物有效抑制了分离的α-葡萄糖苷酶的活性，但对α-淀粉酶的抑制活性有限，这支持了菊苣抑制糖尿病的传统应用。叶提取物还抑制胰脂肪酶和血管紧张素转换酶（ACE）的活性。这些发现表明来自安纳托利亚东部的菊苣在预防代谢综合征方面的潜在应用。皇冠版权所有 (C) 2014 由 Elsevier B.V. 出版。保留所有权利。
In the Eastern Anatolia region of Turkey herbal tea or decoction made of Cichorium intybus L is one of the broadly used traditional herbal remedies to treat diabetes, epilepsy, haemorrhoids, inflammation and digestive disorders. Antioxidant capacity of crude hydrophilic extracts of Eastern Anatolia grown C intybus plant was comparable to numerous common medicinal and Chinese medicinal plants, with leaf exhibiting superior antioxidant potential. Lyophilised hydrophilic extract obtained from leaf comprised of hydroxycinnamic acids and flavonoids, with isomers of chlorogenic acid, caftaric acid, cichoric acid, and luteolin hexoside as the dominating compounds. This extract effectively suppressed the activity of isolated a-glucosidase, but the inhibitory activity towards a-amylase was limited, which supports the traditional application of chicory to suppress diabetes. The leaf extract also suppressed the activities of pancreatic lipase and angiotensin converting enzyme (ACE). These findings suggest potential application of chicory from Eastern Anatolia in the prevention of metabolic syndrome. Crown Copyright (C) 2014 Published by Elsevier B.V. All rights reserved.