Size-Tunable Synthesis of Monodisperse Water-Soluble Gold Nanoparticles with High X-ray Attenuation
Size-Tunable Synthesis of Monodisperse Water-Soluble Gold Nanoparticles with High X-ray Attenuation
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DOI：
10.1002/chem.200902463
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发表时间：
2010-01-01
影响因子：
4.3
通讯作者：
Cai, Wei
中科院分区：
文献类型：
--
作者：
Wang, Zhijiang;Wu, Lina;Cai, Wei
功能性金纳米粒子在生物学中的应用是纳米技术中快速发展且令人兴奋的领域之一。[1-8]能够合成具有受控尺寸或形状的高度稳定的金纳米粒子的方法受到了广泛的研究工作，因为光学、磁力、电子和催化活性等特性都对尺寸敏感。[9-14]为了获得高质量的金纳米粒子，先前的研究已经探索了柠檬酸盐、硫醇盐、磷烷、胺类、羰基化合物的用途。树枝状聚合物和表面活性剂配体以稳定溶液中的金纳米颗粒。[15]特别是，硫醇盐封端的金纳米粒子特别令人感兴趣，因为有机硫醇盐可分离的单层保护的金产品对空气暴露、长期储存和极端浓度表现出极好的稳定性。[16, 17]在用于制备硫醇盐封端的金纳米粒子的方法中，包括配体交换程序和直接合成，Brust 合成被认为是最简单的，并且提供了克级的方法。[18, 19] 该合成分三个步骤进行，如方程式(1)所示–
The use of functional gold nanoparticles in biology is one of the fast-moving and exciting fields in nanotechnology.[1–8] Methods that enable the synthesis of highly stable gold nanoparticles with controlled size or shape has received a widespread research effort because the properties, such as optical, magnetic, electronic, and catalytic activities, are all dimensionally sensitive.[9–14] To obtain high-quality gold nanoparticles, previous studies have explored the utility of citrate, thiolates, phosphanes, amines, carbonyls, dendrimers, and surfactant ligands to stabilize gold nanoparticles in solution.[15] Particularly, thiolate-capped gold nanoparticles are of special interest because the organothiolate isolable monolayer-protected gold products exhibit superb stability to air exposure, long-term storage, and concentration extremes.[16, 17]Among the methods used to prepare thiolate-capped gold nanoparticles, including ligand-exchange procedures and direct synthesis, the Brust synthesis is believed to be the simplest and provides a gram-scale approach.[18, 19] This synthesis proceeds in three steps, as shown in Equations (1)–