Synthetic Biology: Engineering Living Systems from Biophysical Principles
Synthetic Biology: Engineering Living Systems from Biophysical Principles
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DOI：
10.1016/j.bpj.2017.02.013
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发表时间：
2017-03-28
影响因子：
3.4
通讯作者：
Sauro, Herbert M.
中科院分区：
文献类型：
--
作者：
Bartley, Bryan A.;Kim, Kyung;Sauro, Herbert M.
合成生物学是作为一门生物物理学学科创立的，它试图从化学和物理的基本原理来解释生命的起源。现代合成生物学已经被重新发明为一门工程学科，用来设计新的生物体，以及更好地理解基本的生物机制。然而，成功在很大程度上仍然局限于实验室，合成生物学的变革性应用仍处于初级阶段。在这里，我们回顾了生命系统的六个原则，以及它们与工程系统的比较和对比。我们引用合成生物学文献中的具体例子来说明这些原理，并推测它们对进一步研究的影响。为了充分实现合成生物学的前景，我们必须意识到生命的独特性质。
Synthetic biology was founded as a biophysical discipline that sought explanations for the origins of life from chemical and physical first principles. Modern synthetic biology has been reinvented as an engineering discipline to design new organisms as well as to better understand fundamental biological mechanisms. However, success is still largely limited to the laboratory and transformative applications of synthetic biology are still in their infancy. Here, we review six principles of living systems and how they compare and contrast with engineered systems. We cite specific examples from the synthetic biology literature that illustrate these principles and speculate on their implications for further study. To fully realize the promise of synthetic biology, we must be aware of life's unique properties.