Coordinated transcription of key pathways in the mouse by the circadian clock
Coordinated transcription of key pathways in the mouse by the circadian clock
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DOI：
10.1016/s0092-8674(02)00722-5
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发表时间：
2002-05-03
期刊：
影响因子：
64.5
通讯作者：
Hogenesch, JB
中科院分区：
文献类型：
--
作者：
Panda, S;Antoch, MP;Hogenesch, JB
在哺乳动物中，生理和行为的昼夜节律控制是由位于下丘脑视交叉上核（SCN）的主起搏器驱动的。我们使用基因表达谱来识别 SCN 和肝脏中的循环转录本。我们的分析揭示了类似的 650 个循环转录本，并表明其中大多数是 SCN 或肝脏特异的。遗传和基因组分析表明，相对少量的输出基因受核心振荡器组件直接调节。研究发现，视交叉上核和肝脏调节的主要过程受到昼夜节律的调节。重要的是，这些不同途径中的限速步骤是昼夜节律控制的关键位点，凸显了生物钟在细胞和有机体生理学中发挥的基本作用。
In mammals, circadian control of physiology and behavior is driven by a master pacemaker located in the suprachiasmatic nuclei (SCN) of the hypothalamus. We have used gene expression profiling to identify cycling transcripts in the SCN and in the liver. Our analysis revealed similar to650 cycling transcripts and showed that the majority of these were specific to either the SCN or the liver. Genetic and genomic analysis suggests that a relatively small number of output genes are directly regulated by core oscillator components. Major processes regulated by the SCN and liver were found to be under circadian regulation. Importantly, rate-limiting steps in these various pathways were key sites of circadian control, highlighting the fundamental role that circadian clocks play in cellular and organismal physiology.