microRNA-501-3p suppresses metastasis and progression of hepatocellular carcinoma through targeting LIN7A.
microRNA-501-3p suppresses metastasis and progression of hepatocellular carcinoma through targeting LIN7A.
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microRNA-501-3p通过靶向LIN7A抑制肝细胞癌的转移和进展
DOI：
10.1038/s41419-018-0577-y
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发表时间：
2018-05-01
影响因子：
9
通讯作者：
Huang X
中科院分区：
文献类型：
--
作者：
Luo C;Yin D;Zhan H;Borjigin U;Li C;Zhou Z;Hu Z;Wang P;Sun Q;Fan J;Zhou J;Wang X;Zhou S;Huang X
越来越多的证据表明microRNAs（miRNAs）参与了肝细胞癌（HCC）的转移和进展。然而，其在HCC中的具体表达水平和实际功能尚未完全阐明。我们最近的研究结果显示，一些miRNAs与HCC的转移特别相关。miR-501- 3 p是新近发现的miRNAs之一，它高度参与了肝癌的转移过程。在此我们报道了miR-501- 3 p在转移性HCC细胞系和复发转移HCC患者的组织样本中的表达均降低。miR-501- 3 p的下调与HCC患者的肿瘤进展和不良预后相关。功能分析结果显示，miR-501- 3 p在HCCLM 3癌细胞中的过表达抑制了其增殖、迁移、侵袭和上皮-间质转化（EMT），而miR-501- 3 p在PLC/PRF/5癌细胞中的缺失促进了所有这些细胞活性。此外，miR-501- 3 p直接靶向Lin-7同源物A（LIN 7A）以介导对HCC细胞中转移的抑制作用。miR-501- 3 p通过靶向LIN 7A抑制HCC的转移和进展。这一发现表明，miR-501- 3 p可用作潜在的预后预测因子以及HCC治疗的潜在治疗工具。
Increasing numbers of evidences have demonstrated that microRNAs (miRNAs) are implicated in metastasis and progression of hepatocellular carcinoma (HCC). However, their detailed expression levels and actual functions in HCCs have not been fully clarified yet. Results from our recent study revealed that some miRNAs were particularly related to metastasis of HCCs. As one of these newly found miRNAs, miR-501-3p showed to highly involve into metastatic process of HCCs. Here we reported that the expression of miR-501-3p was decreased in both metastatic HCC cell lines and tissue samples from HCC patients with recurrence and metastasis. Downregulation of miR-501-3p correlated with tumor progression and poor prognosis in the HCC patients. Results of functional analyses revealed that overexpression of miR-501-3p in HCCLM3 cancer cells inhibited their proliferation, migration, invasion, and epithelial–mesenchymal transition (EMT), while miR-501-3p loss in PLC/PRF/5 cancer cells facilitated all these cellular activities. In addition, Lin-7 homolog A (LIN7A) was directly targeted by miR-501-3p to mediate the suppression effects on metastasis in HCC cells. miR-501-3p suppresses metastasis and progression of HCCs through targeting LIN7A. This finding suggests that miR-501-3p could be used as a potential prognostic predictor as well as a potential therapeutic tool for HCC therapies.
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影响因子：
--
作者：
Wittekind, C.
通讯作者：
Wittekind, C.
DOI：
10.1056/nejmoa0901282
发表时间：
2009-10-08
期刊：
The New England journal of medicine
影响因子：
--
作者：
Ji J;Shi J;Budhu A;Yu Z;Forgues M;Roessler S;Ambs S;Chen Y;Meltzer PS;Croce CM;Qin LX;Man K;Lo CM;Lee J;Ng IO;Fan J;Tang ZY;Sun HC;Wang XW
通讯作者：
Wang XW
影响因子：
56.9
作者：
Pillai, RS;Bhattacharyya, SN;Filipowicz, W
通讯作者：
Filipowicz, W
影响因子：
29.4
作者：
Meng, Fanyin;Henson, Roger;Patel, Tushar
通讯作者：
Patel, Tushar
DOI：
10.1002/hep.27816
发表时间：
2015-08
期刊：
Hepatology (Baltimore, Md.)
影响因子：
--
作者：
Chuang KH;Whitney-Miller CL;Chu CY;Zhou Z;Dokus MK;Schmit S;Barry CT
通讯作者：
Barry CT