Miscellaneous meroterpenoids from Ganoderma applanatum
Miscellaneous meroterpenoids from Ganoderma applanatum
复制标题
球果灵芝中的杂类萜类化合物
DOI：
10.1016/j.tet.2016.06.019
复制
发表时间：
2016-07-28
期刊：
影响因子：
2.1
通讯作者：
Cheng, Yong-Xian
中科院分区：
文献类型：
--
作者：
Luo, Qi;Yang, Xiao-Hua;Cheng, Yong-Xian
从树舌（Ganoderma applanatum）的子实体中分离得到26个新的高萜类化合物，分别命名为树舌酚C-Z（1-24），Z1（25）和Z2（26）; 3个新的生物碱，分别命名为树舌碱A（27），B（28）和表树舌碱B（29）。除18和25外，其余化合物均为外消旋体，手性HPLC分离得到其各自的对映体。通过光谱和计算方法对这些分离物的结构进行了归属，包括其绝对构型。特别地，1、3和12的结构通过单晶X射线衍射数据确认。评价了所有分离物对考克斯-1和考克斯-2的生物活性，发现化合物Ia具有考克斯-2抑制作用，IC 50值为25.5 μ M。(C)2016爱思唯尔有限公司版权所有
Twenty-six new meroterpenoids, applanatumols C-Z (1-24), Zl (25) and Z2 (26), and three new alkaloids, ganoapplanatumines A (27), B (28) and epi-ganoapplanatumine B (29), were isolated from the fruiting bodies of Ganoderma applanatum. With exception of 18 and 25, all the other compounds are racemates, Chiral HPLC separation afforded their respective enantiomers. The structures of these isolates including their absolute configurations were assigned by spectroscopic and computational methods. In particular, the structures of 1, 3 and 12 were confirmed by single crystal X-ray diffraction data. Biological activities of all the isolates against COX-1 and COX-2 were evaluated, compound la was found to have COX-2 inhibitory effect with IC50 value of 25.5 mu M. (C) 2016 Elsevier Ltd. All rights reserved.