Estradiol alleviates depressive-like symptoms in a novel animal model of post-partum depression
Estradiol alleviates depressive-like symptoms in a novel animal model of post-partum depression
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DOI：
10.1016/s0166-4328(01)00170-x
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发表时间：
2001-07-01
影响因子：
2.7
通讯作者：
Barr, AM
中科院分区：
文献类型：
--
作者：
Galea, LAN;Wide, JK;Barr, AM
本研究以雌性Long-Evans大鼠为实验对象，观察了模拟妊娠后激素戒断对强迫游泳试验（FST）中抑郁样行为的影响。将雌性动物随机分配至“妊娠”、“妊娠”+苯甲酸雌二醇（EB）和对照组。“妊娠”组和“妊娠”+ EB组每天接受雌二醇和孕酮激素注射，以模拟大鼠23天的妊娠期。然而，“怀孕”+ EB组在“怀孕”后继续接受每日雌二醇注射。在妊娠期最后一次注射后48小时，在FST和随后的旷场试验（OFT）中对所有组进行检测。结果显示，与“妊娠”+ EB组和对照组相比，“妊娠”大鼠表现出显著增加的不动性和减少的挣扎和游泳行为。这些发现不能被解释为一个整体抑郁症的一般运动活动中的“怀孕”的大鼠，因为“怀孕”的大鼠作出更多的区域交叉的OFT。因此，“怀孕”大鼠表现出与“产后”（在其激素方案停止后）的“抑郁样”症状一致的行为。然而，在“怀孕”+ EB组中持续高水平雌二醇治疗，逆转了这些行为的表现。这些结果意味着，从长期高水平的妊娠相关激素（雌二醇和孕酮）的撤退可以产生抑郁症的啮齿动物，这可以通过延长暴露于高水平的雌二醇通过产后期预防。这些发现首次证明了产后妊娠啮齿动物模型中的“抑郁样”症状以及高水平雌二醇减轻这些“抑郁样”症状的能力。(C)2001 Elsevier Science B. V.保留所有权利。
The effect of hormone withdrawal following hormone-simulated "pregnancy" on "depressive-like behavior" in the Forced Swim Test (FST) was investigated in female Long-Evans rats. Females were randomly assigned to "pregnant", "pregnant" + estradiol benzoate (EB), and control groups. Both the "pregnant" and "pregnant" + EB groups received daily injections of the hormones estradiol and progesterone to simulate the 23-day gestational period in the rat. However, the "pregnant" + EB group continued to receive daily estradiol injections after "pregnancy". All groups were tested 48 h after the last injection of the pregnancy period in the FST and subsequently in the Open Field Test (OFT). Results revealed that the "pregnant" rats exhibited significantly increased immobility and decreased struggling and swimming behaviors as compared to the "pregnant" + EB and control groups. These findings could not be explained by an overall depression in general locomotor activity among "pregnant" rats, as the "pregnant" rats made more area crossings in the OFT. Thus "pregnant" rats exhibited behaviors consistent with "depressive-like" symptoms "post-partum" (after their hormone regime was discontinued). Continual treatment with high levels of estradiol in the "pregnant" + EB group, however, reversed the exhibition of these behaviors. These results imply that withdrawal from chronic high levels of pregnancy-associated hormones (estradiol and progesterone) can produce depressed symptomology in rodents, which can be prevented by prolonging exposure to high levels of estradiol through the post-partum period. These findings are the first demonstration of "depressive-like" symptoms in a rodent model of post-partum pregnancy and the ability of high levels of estradiol to attenuate these ''depressive-like" symptoms. (C) 2001 Elsevier Science B.V. All rights reserved.