Role of type-specific neuron properties in a spinal cord motor network
Role of type-specific neuron properties in a spinal cord motor network
复制标题
类型特异性神经元特性在脊髓运动网络中的作用
DOI：
10.1007/s10827-006-0019-1
复制
发表时间：
2007
影响因子：
1.2
通讯作者：
A. Roberts
中科院分区：
文献类型：
--
作者：
Bart Sautois;S. Soffe;Wen;A. Roberts
最近的记录从脊髓神经元在孵化青蛙蝌蚪允许其类型的特定属性被定义。参与游泳控制的七种主要神经元类型已被鉴定。为了研究类型特定属性的重要性，我们构建了每种神经元类型的模型，并使用感觉神经元、感觉通路中间神经元、中央模式发生器（CPG）中间神经元和运动神经元之间的已知连接性将它们组装成网络。对感觉神经元的单一刺激启动游泳，其中模拟的神经元和网络活动与生理活动平行。神经元类型之间的放电特性的替代表明，兴奋性CPG中间神经元的放电特性对于稳定的游泳是至关重要的。我们认为，特定类型的神经元特性可以反映参与一种特定网络反应（如游泳）的需求，但也可能反映参与多种反应（如游泳和缓慢挣扎）的需求。
Recent recordings from spinal neurons in hatchling frog tadpoles allow their type-specific properties to be defined. Seven main types of neuron involved in the control of swimming have been characterized. To investigate the significance of type-specific properties, we build models of each neuron type and assemble them into a network using known connectivity between: sensory neurons, sensory pathway interneurons, central pattern generator (CPG) interneurons and motoneurons. A single stimulus to a sensory neuron initiates swimming where modelled neuronal and network activity parallels physiological activity. Substitution of firing properties between neuron types shows that those of excitatory CPG interneurons are critical for stable swimming. We suggest that type-specific neuronal properties can reflect the requirements for involvement in one particular network response (like swimming), but may also reflect the need to participate in more than one response (like swimming and slower struggling).
影响因子：
2.5
作者：
Jezzini, SH;Hill, AAV;Calabrese, RL
通讯作者：
Calabrese, RL