Palladium-catalyzed selective oxidative olefination and arylation of 2-pyridones
Palladium-catalyzed selective oxidative olefination and arylation of 2-pyridones
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钯催化 2-吡啶酮的选择性氧化烯化和芳基化
DOI：
10.1039/c2sc20869e
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发表时间：
2012-11-01
期刊：
影响因子：
8.4
通讯作者：
Li, Xingwei
中科院分区：
文献类型：
--
作者：
Chen, Yuye;Wang, Fen;Li, Xingwei
在钯催化下，实现了n -保护2-吡啶酮的底物控制选择性氧化烯烃反应。n保护的简单吡啶酮具有5位选择性。在4位或6位上引入取代基将位点选择性转变为3位。二烯烃也可以高效地实现。与多氟苯的氧化芳基化具有类似的选择性，除了该系统对空间和电子的要求更高。
Substrate-controlled selective oxidative olefination of N-protected 2-pyridones has been achieved under palladium catalysis. The 5-position selectivity was followed for N-protected simple pyridones. Introduction of substituents into the 4- or the 6-position switched the site selectivity to the 3-position. Diolefination can also be achieved with high efficiency. Oxidative arylation with polyfluorobenzenes followed a similar selectivity except that the system is more sterically and electronically demanding.