Dose-dependent therapeutic antiinfectives from ethnomedicines of bay islands
Dose-dependent therapeutic antiinfectives from ethnomedicines of bay islands
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DOI：
10.1159/000092859
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发表时间：
2006-01-01
期刊：
影响因子：
3.3
通讯作者：
Bhattacharya, S. K.
中科院分区：
文献类型：
--
作者：
Chattopadhyay, D.;Arunachalam, G.;Bhattacharya, S. K.
背景资料：研究了小安达曼岛民族药烟根、灯心草和白背桐的甲醇提取物的抗感染、抗氧化和抗氧化活性。方法：在细胞和动物模型中测定毒性。抗病毒，抗菌和抗真菌活性测定空斑减少，光盘扩散和琼脂稀释法。并对其抗氧化活性进行了研究。结果：300 μ g/ml的烟草O.nicobarica具有抗HSV活性，而M. peltatus和A.大叶藻在64- 1000 μ g/ml范围内具有抗菌活性。两种提取物在无毒浓度下均表现出显著的剂量依赖性抗氧化活性。结论：从活性部位中分离的生物碱、黄酮和β-谷甾醇具有剂量依赖性的治疗作用，证明了它们的应用。需要进一步研究才能了解其作用机制。
Background: The methanol extract of Ophirrhiza nicobarica, Alstonia macrophylla and Mallotus peltatus, ethnomedicines of Little Andaman, were investigated for antiinfective, antiinflammatory and antioxidant activities. Methods: Toxicity was determined in cells and in an animal model. Antiviral, antibacterial and antifungal activity was determined by plaque reduction, disc diffusion and agar dilution methods. The antiinflammatory and antioxidant activities were also studied. Results: O.nicobarica at 300 mu g ml(-1) showed anti-HSV activity while M. peltatus and A. macrophylla showed antibacterial activity at 64-1,000 mu g ml(-1). Both extracts showed significant dose-dependent antiinflammatory and antioxidant activity at nontoxic concentrations. Conclusion: The alkaloid, flavonoid and beta-sitosterol isolated from bioactive parts had a dose-dependent therapeutic efficacy, justifying their use. Further study is required to know the mechanism of action.