A NEW MEMBER OF THE CYTOKINE RECEPTOR GENE FAMILY MAPS ON CHROMOSOME-21 AT LESS-THAN 35 KB FROM IFNAR
A NEW MEMBER OF THE CYTOKINE RECEPTOR GENE FAMILY MAPS ON CHROMOSOME-21 AT LESS-THAN 35 KB FROM IFNAR
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DOI：
10.1006/geno.1993.1199
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发表时间：
1993-05-01
期刊：
影响因子：
4.4
通讯作者：
UZE, G
中科院分区：
文献类型：
--
作者：
LUTFALLA, G;GARDINER, K;UZE, G
克隆了对应于定位到D21 S58基因座的基因的全长cDNA。编码的蛋白质称为CRF 2 -4，被证明是细胞因子受体家族的典型II类成员。编码CRF 2 -4的基因跨度超过30 kb。它的内含子/外显子结构被确定，并显示与细胞因子受体家族的所有其他成员是保守的。CRF 2 -4基因和它的IFNAR邻居之间的物理距离已经被缩小到小于35 kb。
A full-length cDNA corresponding to a gene mapping to the D21S58 locus was cloned. The encoded protein, called CRF2-4, was shown to be a typical class II member of the cytokine receptor family. The gene encoding CRF2-4 spans more than 30 kb. Its intron/exon structure was determined and shown to be conserved with all other members of the cytokine receptor family. The physical distance between the CRF2-4 gene and its IFNAR neighbor has been narrowed to less than 35 kb.