Immunoglobulin E receptor signaling and asthma.
Immunoglobulin E receptor signaling and asthma.
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DOI：
10.1074/jbc.r110.205104
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发表时间：
2011-09-23
期刊：
影响因子：
--
通讯作者：
Wu LC
中科院分区：
文献类型：
--
作者：
Wu LC
IgE水平升高和IgE对过敏原的增敏是过敏性哮喘的主要特征。IgE与肥大细胞、嗜碱性粒细胞和树突状细胞上的高亲和力Fcε受体I（FcεRI）结合，并在抗原诱导IgE结合的FcεRI交联后介导这些细胞的活化。Fc β RI活化通过信号分子和衔接蛋白的网络进行，并受许多细胞表面和细胞内蛋白的负调控。中重度过敏性哮喘患者血清IgE的治疗性中和可通过减少细胞表面FcεRI表达降低哮喘急性发作的频率，从而降低Fc εRI活化，从而改善哮喘控制。我们对IgE受体信号传导的理解不断增加，这可能会导致开发新的治疗哮喘的药物。
Elevated IgE levels and increased IgE sensitization to allergens are central features of allergic asthma. IgE binds to the high-affinity Fcϵ receptor I (FcϵRI) on mast cells, basophils, and dendritic cells and mediates the activation of these cells upon antigen-induced cross-linking of IgE-bound FcϵRI. FcϵRI activation proceeds through a network of signaling molecules and adaptor proteins and is negatively regulated by a number of cell surface and intracellular proteins. Therapeutic neutralization of serum IgE in moderate-to-severe allergic asthmatics reduces the frequency of asthma exacerbations through a reduction in cell surface FcϵRI expression that results in decreased FcϵRI activation, leading to improved asthma control. Our increasing understanding of IgE receptor signaling may lead to the development of novel therapeutics for the treatment of asthma.