Influence of heterogeneous and anisotropic tissue conductivity on electric field distribution in deep brain stimulation
Influence of heterogeneous and anisotropic tissue conductivity on electric field distribution in deep brain stimulation
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DOI：
10.1007/s11517-011-0842-z
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发表时间：
2012-01-01
影响因子：
3.2
通讯作者：
Wardell, Karin
中科院分区：
文献类型：
--
作者：
Astrom, Mattias;Lemaire, Jean-Jacques;Wardell, Karin
目的是量化异质各向同性和异质各向异性组织对脑深部电刺激（DBS）过程中电场空间分布的影响。为接受DBS治疗的1例患者创建了3个有限元组织模型。将组织电导率建模为（I）均匀各向同性，（II）基于MRI的非均匀各向同性，以及（III）基于扩散张量MRI的非均匀各向异性。在每个组织模型中，将模拟DBS电极定位在丘脑底区、苍白球和内囊中。对每个模型和目标组合模拟DBS期间产生的电场，并在0.20（内部）和0.05 V mm（-1）（外部）处使用等电平进行可视化。统计和矢量分析用于评价电场的分布。异质各向同性的组织改变了电场的空间分布高达4%的内部，并高达10%的外部isollevel。异质各向异性组织的电场分布的影响高达18%和15%，在每个isolevels，分别。异质性和各向异性组织对电场的影响可能与解剖区域的临床相关，这些解剖区域在功能上被细分并被多个通道纤维包围。
The aim was to quantify the influence of heterogeneous isotropic and heterogeneous anisotropic tissue on the spatial distribution of the electric field during deep brain stimulation (DBS). Three finite element tissue models were created of one patient treated with DBS. Tissue conductivity was modelled as (I) homogeneous isotropic, (II) heterogeneous isotropic based on MRI, and (III) heterogeneous anisotropic based on diffusion tensor MRI. Modelled DBS electrodes were positioned in the subthalamic area, the pallidum, and the internal capsule in each tissue model. Electric fields generated during DBS were simulated for each model and target-combination and visualized with isolevels at 0.20 (inner), and 0.05 V mm(-1) (outer). Statistical and vector analysis was used for evaluation of the distribution of the electric field. Heterogeneous isotropic tissue altered the spatial distribution of the electric field by up to 4% at inner, and up to 10% at outer isolevel. Heterogeneous anisotropic tissue influenced the distribution of the electric field by up to 18 and 15% at each isolevel, respectively. The influence of heterogeneous and anisotropic tissue on the electric field may be clinically relevant in anatomic regions that are functionally subdivided and surrounded by multiple fibres of passage.