Mechanism of Alkylation of Nucleic Acids by Nitrosodimethylamine
Mechanism of Alkylation of Nucleic Acids by Nitrosodimethylamine
复制标题
亚硝基二甲胺烷基化核酸的机理
作者：
W. Lijinsky;J. Loo;A. Ross
SINCE it was discovered1 that nitrosodimethylamine givdes rise to alkylated nucleic acids in the liver when injected into rats, and that an alkylated base, 7-methylguanine, can be isolated from these nucleic acids, there has been much evidence of a correlation between carcinogenicity of N-nitrosamines and their transformation in vivo into an alkylating agent2–4. There was evidence that the initial step in the conversion of the nitrosamine to an alkylating agent was an enzymatic oxidative dealkylation to a hypothetical monoalkylnitrosamine which was then converted to a diazoalkane or, by some other route, to a carbonium ion. No evidence of the production of a diazoalkane in this way has been presented, although this possibility has been widely postulated5–8.
