Traumatic Brain Injury Activation of the Adult Subventricular Zone Neurogenic Niche.
Traumatic Brain Injury Activation of the Adult Subventricular Zone Neurogenic Niche.
复制标题
成人室内神经源性小众的创伤性脑损伤激活。
DOI：
10.3389/fnins.2016.00332
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发表时间：
2016
影响因子：
4.3
通讯作者：
Szele FG
中科院分区：
文献类型：
--
作者：
Chang EH;Adorjan I;Mundim MV;Sun B;Dizon ML;Szele FG
创伤性脑损伤在平民和军事生活中都很常见，给幸存者和社会带来了巨大的负担。然而，随着包括人类在内的成年哺乳动物对神经干细胞的识别，利用这些细胞修复受损的大脑成为可能，而以前这被认为是不可能的。在这篇综述中，我们集中在啮齿动物成体脑室下区(SVZ)，这是成熟大脑中一个重要的神经源性利基，神经干细胞继续存在于其中。我们回顾了SVZ是如何在细胞增殖、迁移、存活和分化方面受到不同动物TBI模型的干扰的，我们还回顾了参与这些过程的特定分子。总而言之，这些信息建议了下一步尝试将脑损伤动物模型的知识转化为脑损伤的人类疗法。
Traumatic brain injury (TBI) is common in both civilian and military life, placing a large burden on survivors and society. However, with the recognition of neural stem cells in adult mammals, including humans, came the possibility to harness these cells for repair of damaged brain, whereas previously this was thought to be impossible. In this review, we focus on the rodent adult subventricular zone (SVZ), an important neurogenic niche within the mature brain in which neural stem cells continue to reside. We review how the SVZ is perturbed following various animal TBI models with regards to cell proliferation, emigration, survival, and differentiation, and we review specific molecules involved in these processes. Together, this information suggests next steps in attempting to translate knowledge from TBI animal models into human therapies for TBI.