Pituitary antibodies in women with Hashimoto's thyroiditis: prevalence in diagnostic and prediagnostic sera.
Pituitary antibodies in women with Hashimoto's thyroiditis: prevalence in diagnostic and prediagnostic sera.
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桥本甲状腺炎女性的垂体抗体：诊断和诊断前血清中的患病率。
DOI：
10.1089/thy.2011.0373
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
Caturegli,Patrizio
中科院分区：
文献类型：
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作者：
Guaraldi,Federica;Landek-Salgado,MelissaA;Hutfless,Susan;Samoni,Francesca;Talor,MonicaV;Matos,PeterG;Salvatori,Roberto;Rose,NoelR;Caturegli,Patrizio
背景：已报道的垂体抗体与更高的频率在桥本甲状腺炎患者比在健康对照组，虽然有显着的变化强度的关联和所使用的methodology.Methods：我们设计了一个巢式病例对照研究，以表征垂体抗体的患病率在桥本甲状腺炎的临床诊断时，以及在2，5和7年前诊断。使用1998年1月至2007年12月期间的国防医疗监督系统数据库（DMSSD）选择了现役女性服役人员病例（n=87）和匹配的女性对照（n=107）。用免疫荧光法检测垂体抗体，以尸检时收集的人垂体为substrate.Results：在诊断时，垂体抗体存在于9%的桥本氏病例（87例中的8例）和3%的对照（107例中的3例）。当使用条件逻辑回归模型分析数据时，考虑到年龄和工作状态的匹配，在调整DMSSD类别中的种族成分和甲状腺过氧化物酶抗体后，垂体抗体使桥本甲状腺炎的几率增加了7倍（95%置信区间为1.3 - 40.1，p =0.028）。诊断前，垂体抗体阳性的11名受试者（2例和1个对照）在-2年的时间点，和阴性的所有11名受试者在-5和-7年的时间point.Conclusions：总之，使用巢式病例对照设计，我们证实，垂体抗体是更常见的桥本甲状腺炎，并建议他们出现在其自然病程的晚期。
Background:Pituitary antibodies have been reported with greater frequency in patients with Hashimoto's thyroiditis than in healthy controls, although there is significant variability in the strength of the association and the methodologies used.Methods:We designed a nested case–control study to characterize the prevalence of pituitary antibodies at the time of the clinical diagnosis of Hashimoto's thyroiditis, as well as at 2, 5, and 7 years before diagnosis. Active component female service member cases (n=87) and matched female controls (n=107) were selected using the Defense Medical Surveillance System database (DMSSD) between January 1998 and December 2007. Pituitary antibodies were measured by immunofluorescence using human pituitary glands collected at autopsy as the substrate.Results:At diagnosis, pituitary antibodies were present in 9% of cases with Hashimoto's (8 of 87) and 3% of controls (3 of 107). When the data were analyzed using a conditional logistic regression model, which takes into account the matching on age and work status, pituitary antibodies increased the odds of having Hashimoto's thyroiditis by sevenfold (95% confidence interval from 1.3 to 40.1,p=0.028), after adjusting for components of the DMSSD-category-termed race and for thyroperoxidase antibodies. Before diagnosis, pituitary antibodies were positive in 3 of the 11 subjects (2 cases and 1 control) at the −2-year time point, and negative in all 11 subjects at the −5- and −7-year time points.Conclusions:In summary, using a nested case–control design, we confirm that pituitary antibodies are more common in Hashimoto's thyroiditis and suggest that they appear late during its natural history.