Curcumin, a natural plant phenolic food additive, inhibits cell proliferation and induces cell cycle changes in colon adenocarcinoma cell lines by a prostaglandin-independent pathway
Curcumin, a natural plant phenolic food additive, inhibits cell proliferation and induces cell cycle changes in colon adenocarcinoma cell lines by a prostaglandin-independent pathway
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DOI：
10.1016/s0022-2143(97)90107-4
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发表时间：
1997-12-01
期刊：
影响因子：
--
通讯作者：
Rigas, B
中科院分区：
文献类型：
--
作者：
Hanif, R;Qiao, L;Rigas, B
姜黄素是植物姜黄（Curcuma long Linn）根茎的活性成分，姜黄素是一种常用香料，可预防动物肿瘤模型中的癌症。其作用机制尚不清楚；姜黄素可能通过抑制花生四烯酸代谢发挥作用。为了探讨姜黄素化学预防作用的机制，我们研究了ifs在HT-29和HCT-15人结肠癌细胞系增殖和凋亡中的作用，姜黄素剂量依赖性地降低了两种细胞系的增殖率，导致48小时内降低96%。没有检测到细胞凋亡。细胞在细胞周期的G2/M期积累，从而产生抗增殖作用。姜黄素在两种细胞系中的作用相似，但产生前列腺素的能力不同。我们得出结论，姜黄素在体外主要通过在 G2/M 期积累细胞来抑制结肠癌细胞增殖，并且这种作用与其抑制前列腺素合成的能力无关。姜黄素在人类结肠癌中的抗增殖作用的作用仍有待确定。
Curcumin, the active ingredient of the rhizome of the plant turmeric (Curcuma longer Linn), a commonly used spice, prevents cancer in animal tumor models. Its mechanism of action is unknown; curcumin may act by inhibiting arachidonic acid metabolism. To explore the mechanism of curcumin's chemopreventive effect, we studied ifs role in proliferation and apoptosis in the HT-29 and HCT-15 human colon cancer cell lines, Curcumin dose-dependently reduced the proliferation rate of both cell lines, causing a 96% decrease by 48 hours. No apoptosis was detected. The antiproliferative effect was preceded by accumulation of the cells in the G2/M phase of cell cycle. The effect of curcumin was similar in both cell lines, which, however, differ in their ability to produce prostaglandins, We conclude that curcumin inhibits colon cancer cell proliferation in vitro mainly by accumulating cells in the G2/M phase and that this effect is independent of its ability to inhibit prostaglandin synthesis. The role of curcumin's antiproliferative effect in human colon cancer remains to be established.