Amnesia in monkeys after lesions of the mediodorsal nucleus of the thalamus.
Amnesia in monkeys after lesions of the mediodorsal nucleus of the thalamus.
复制标题
丘脑内侧核损伤后猴子的失忆症。
DOI：
10.1002/ana.410170605
复制
发表时间：
1985
影响因子：
11.2
通讯作者：
Squire,LR
中科院分区：
文献类型：
--
作者：
Zola-Morgan,S;Squire,LR
最近在猴子身上成功地建立了人类健忘症的动物模型，这使得确定间脑和内侧颞区的特定结构在受损时导致健忘症成为可能。猴子的小损伤主要局限于丘脑中背核的后部，对它们进行了对人类健忘症敏感的记忆测试，以及类似于狂躁症患者通常执行的基于技能的任务的第二项测试。猴子在第一次测试中表现出明显的缺陷，在第二次测试中表现正常。结果表明，中背核的局限性病变可引起严重的健忘症。
Recent successes in developing an animal model of human amnesia in the monkey have made it feasible to try to identify with certainty the specific structures in the diencephalon and medial temporal region that cause amnesia when damaged. Monkeys with small lesion restricted largely to the posterior portion of the mediodorsal nucleus of the thalamus were given a test of memory sensitive to human amnesia and a second test that is analogous to the skill‐based tasks performed normally by manesic patients. The monkeys exhibited a marked impairment on the first test and performed normally on the second. The results show that circumscribed lesions of the mediodorsal nucleus can cause substantial amnesia.