Glucose utilization by the polyol pathway in human erythrocytes.
Glucose utilization by the polyol pathway in human erythrocytes.
复制标题
人红细胞中多元醇途径对葡萄糖的利用。
DOI：
10.1016/0006-291x(70)91066-1
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发表时间：
1970
影响因子：
3.1
通讯作者：
A. Winegrad
中科院分区：
文献类型：
--
作者：
Anthony D. Morrison;Rex S. Clements;Susan B. Travis;F. A. Oski;A. Winegrad
山梨糖醇在人红细胞中的浓度超过血浆中的浓度，并且与血浆葡萄糖浓度线性相关。当红细胞在含有增加的葡萄糖浓度的培养基中孵育时，细胞内山梨糖醇和果糖浓度增加，培养基中出现游离果糖。在5 mM的中等葡萄糖浓度下，约3%的葡萄糖摄取用于山梨糖醇和果糖的合成。葡萄糖似乎是红细胞中糖醇：NADP氧化还原酶的生理底物。
Sorbitol is present in human erythrocytes in concentrations exceeding that in plasma, and is linearly related to the plasma glucose concentration. When erythrocytes are incubated in media containing increasing glucose concentrations, the intracellular sorbitol and fructose concentrations increase and free fructose appears in the media. At a medium glucose concentration of 5 mM approximately 3% of the glucose uptake is utilized for sorbitol and fructose synthesis.Glucose appears to be a physiological substrate for alditol:NADP oxidoreductase in the erythrocyte.