Redefining Noradrenergic Neuromodulation of Behavior: Impacts of a Modular Locus Coeruleus Architecture
Redefining Noradrenergic Neuromodulation of Behavior: Impacts of a Modular Locus Coeruleus Architecture
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DOI：
10.1523/jneurosci.1164-19.2019
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发表时间：
2019-10-16
影响因子：
5.3
通讯作者：
Totah, Nelson K.
中科院分区：
文献类型：
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作者：
Chandler, Dan J.;Jensen, Patricia;Totah, Nelson K.
蓝斑 (LC) 是一个看似单一且紧凑的神经调节核，由于其在整个中枢神经系统中广泛的去甲肾上腺素能投射，它是不同脑功能理论的重要组成部分。作为一种弥漫性神经调节系统，去甲肾上腺素影响学习和决策、睡眠和觉醒的控制、包括疼痛在内的感觉显着性、相关前脑活动（整体和网络）的生理学以及大脑血流动力学反应。然而，由于最先进的方法的应用揭示了许多提供有针对性的神经调节的模块的核心，我们对 LC 的理解正在发生巨大的转变。在这里，我们回顾了支持基于多个观察水平（发育、遗传、分子、解剖和神经生理学）的模块化 LC 的证据。我们建议必须重新考虑 LC 作为单一核的概念，以及 LC 在不同脑功能理论中的作用。
The locus coeruleus (LC) is a seemingly singular and compact neuromodulatory nucleus that is a prominent component of disparate theories of brain function due to its broad noradrenergic projections throughout the CNS. As a diffuse neuromodulatory system, noradrenaline affects learning and decision making, control of sleep and wakefulness, sensory salience including pain, and the physiology of correlated forebrain activity (ensembles and networks) and brain hemodynamic responses. However, our understanding of the LC is undergoing a dramatic shift due to the application of state-of-the-art methods that reveal a nucleus of many modules that provide targeted neuromodulation. Here, we review the evidence supporting a modular LC based on multiple levels of observation (developmental, genetic, molecular, anatomical, and neurophysiological). We suggest that the concept of the LC as a singular nucleus and, alongside it, the role of the LC in diverse theories of brain function must be reconsidered.