Cutaneous interleukin-7 transgenic mice display a propitious environment to Schistosoma mansoni infection
Cutaneous interleukin-7 transgenic mice display a propitious environment to Schistosoma mansoni infection
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DOI：
10.1046/j.1365-3024.2001.00365.x
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发表时间：
2001-03-01
影响因子：
2.2
通讯作者：
Wolowczuk, I
中科院分区：
文献类型：
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作者：
Roye, O;Delacre, M;Wolowczuk, I
白细胞介素（IL）-7在曼氏血吸虫感染的人和鼠皮肤中早期产生，并且最近显示有利于寄生虫发育。在目前的工作中，我们研究了角质形成细胞衍生的IL-7在这个过程中的参与。角质形成细胞是表皮的主要细胞成分，也是寄生虫感染脊椎动物宿主时首先遇到的组织。因此，我们感染IL-7皮肤转基因小鼠，并比较了几个寄生虫学和免疫学参数的感染同窝对照。在转基因小鼠中，观察到蠕虫总数增加，而卵数和雌性生殖力保持不变。此外，转基因动物表现出更严重的肝纤维化。与此同时，感染的IL-7转基因动物表现出对卵抗原的显性Th 2型体液应答。本研究结果证实并加强了IL-7在S.曼氏-脊椎动物宿主相互作用，开始于角质形成细胞衍生的IL-7。
Interleukin (IL)-7 is produced early in Schistosoma mansoni infected human and murine skin and was recently shown to favour parasite development. In the present work, we investigated the participation of keratinocyte-derived IL-7 in this process. Keratinocytes are the predominant cellular constituents of the epidermis and the first tissue encountered by the parasite when it infects the vertebrate host. We therefore infected IL-7 cutaneous transgenic mice and compared several parasitological and immunological parameters to those of infected littermate controls. In transgenic mice, an increased number of total adult worms was observed while egg number and female fecundity remained unchanged. Additionally, transgenic animals displayed a more intensive hepatic fibrosis. In parallel, infected IL-7 transgenic animals showed a dominant Th2-type humoral response towards egg antigens. The results presented here confirm and reinforce the key role play by IL-7 in S. mansoni-vertebrate host interplay, beginning with keratinocyte-derived IL-7.