Lipid profile, obesity and bone mineral density: the Hertfordshire Cohort Study.
Lipid profile, obesity and bone mineral density: the Hertfordshire Cohort Study.
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脂质谱，肥胖和骨矿物质密度：赫特福德郡队列研究。
DOI：
10.1093/qjmed/hcm023
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发表时间：
2007-05
影响因子：
13.3
通讯作者：
Cooper, C
中科院分区：
文献类型：
--
作者：
Dennison, E M;Syddall, H E;Aihie Sayer, A;Martin, H J;Cooper, C
多项研究表明，体重指数 (BMI) 和骨矿物质密度 (BMD) 呈正相关，但有关骨密度、血脂和人体测量指标的数据很少。我们在一大群特征明确的男性和女性中探讨了这些关系（英国赫特福德郡队列研究）。来自英国赫特福德郡的 465 名男性和 448 名女性被招募。提供了关于人口和生活方式因素、人体测量、体脂百分比、空腹甘油三酯、胆固醇（总胆固醇、高密度脂蛋白、低密度脂蛋白）、载脂蛋白（a）和载脂蛋白（b）的信息；记录腰椎和总股骨的骨矿物质密度（BMD）。腰椎（男性 r=0.15，p=0.001；女性 r=0.14 p=0.003）和整个股骨区域（男性 r=0.18，p=0.0001；女性 r==0.16，p=0.0008）的 BMD 与血清甘油三酯水平相关，即使在调整腰臀比、年龄、社会阶层和生活方式因素后也是如此，但如果身体脂肪则不然在回归模型中用百分比代替腰臀比。空腹HDL胆固醇水平与女性腰椎BMD（r=-0.15，p=0.001）和总股骨BMD（男性r=-0.15，p=0.002；女性r=-0.23，p<0.0001）相关；这些关系也因调整身体脂肪百分比而不是腰臀比而减弱。总胆固醇或低密度脂蛋白胆固醇与骨密度之间没有关系。我们已经证明了血脂谱和 BMD 之间的关系对于调整中心性肥胖（腰臀比）的一项指标（腰臀比）非常有效，但对全身脂肪却没有影响。
Body mass index (BMI) and bone mineral density (BMD) are positively correlated in several studies, but few data are available relating bone density, lipid profile and anthropometric measures. We addressed these relationships in a large well-characterised cohort of men and women (The Hertfordshire Cohort Study, UK). Four hundred and sixty five men and 448 women from Hertfordshire, UK were recruited. Information was available on demographic and lifestyle factors, anthropometric measurements, body fat percentage, fasting triglycerides, cholesterol (total, HDL, LDL), apolipoprotein (a) and apolipoprotein (b); bone mineral density (BMD) was recorded at the lumbar spine and total femur. BMD at the lumbar spine (males r=0.15, p=0.001; females r=0.14 p=0.003) and total femoral region (males r=0.18, p=0.0001; females r==0.16, p=0.0008) was related to serum triglyceride level, even after adjustment for waist hip ratio, age, social class and lifestyle factors, but not if body fat percentage was substituted for waist-hip ratio in the regression model. Fasting HDL cholesterol level was related to lumbar spine BMD in women (r=−0.15, p=0.001) and total femoral BMD (males r=−0.15, p=0.002; females r=−0.23, p<0.0001); these relationships were also attenuated by adjustment for body fat percentage but not waist hip ratio. No relationships were seen between total or LDL cholesterol with BMD. We have demonstrated relationships between lipid profile and BMD that are robust to adjustment for one measure of central obesity (waist-hip ratio) but not total body fat.