Association between Apolipoprotein C-III Gene Polymorphisms and Coronary Heart Disease: A Meta-analysis.
Association between Apolipoprotein C-III Gene Polymorphisms and Coronary Heart Disease: A Meta-analysis.
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DOI：
10.14336/ad.2015.0709
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发表时间：
2016-02
影响因子：
7.4
通讯作者：
Jingzhan Zhang;Xiang Xie;Yi-tong Ma;Ying-Ying Zheng-Ying;Yining Yang;Xiaomei Li;Z. Fu;C. Dai;Ming-Ming Zhang-Ming;G. Yin;Fen Liu;Bang-dang Chen;M. Gai
中科院分区：
文献类型：
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作者：
Jingzhan Zhang;Xiang Xie;Yi-tong Ma;Ying-Ying Zheng-Ying;Yining Yang;Xiaomei Li;Z. Fu;C. Dai;Ming-Ming Zhang-Ming;G. Yin;Fen Liu;Bang-dang Chen;M. Gai
载脂蛋白C-III（APOC 3）基因多态性已被报道与冠心病（CHD）相关，但迄今为止的数据一直相互矛盾。为了更精确地估计这些关联，我们进行了一项荟萃分析，以调查所有已发表研究中APOC 3的三种主要多态性（Sst I，T-455 C，C-482 T）。系统检索PubMed、Web of Science、万方、SinoMed、CNKI等数据库。使用比值比（OR）和95%置信区间（CI）评估相关性。使用Review Manager 5.3.3和Stata 12.0进行统计分析。共确定了31项研究。采用随机效应模型和固定效应模型计算APOC 3基因多态性与冠心病相关性的合并优势比（OR）及其95%可信区间（95% CI）。在等位基因对比模型下观察到APOC 3 SstI多态性与CHD易感性之间的统计相关性（P= 0.003，OR = 1.14，95%CI = 1.05-1.24），显性遗传模型隐性遗传模型（P = 0.02，OR = 1.35，95% CI = 1.06-1.71）。在等位基因对比下，APOC 3 T-455 C多态性与CHD之间也存在显著关联（P < 0.0001，OR = 1.19，95%CI = 1.10-1.29），显性遗传模型（P= 0.0003，OR = 1.24，95% CI = 1.11-1.39）和隐性遗传模型（P= 0.04，OR = 1.30，95% CI = 1.01-1.67）。在等位基因模型下，未发现APOC 3 C-482 T多态性与CHD有显著关联（P= 0.94，OR = 1.00，95%CI = 0.93-1.08），显性遗传模型（P= 0.20，OR = 1.07，95% CI = 0.97-1.18）或隐性遗传模型（P= 0.13，OR = 0.90，95% CI = 0.79-1.03）。这项荟萃分析显示，APOC 3 Sst I和T-455 C多态性显着增加CHD的易感性。APOC 3 C-482 T多态性与CHD易感性无显著相关性。
Polymorphisms in the apolipoprotein C-III (APOC3) gene have been reported to be associated with coronary heart disease (CHD), but the data so far have been conflicting. To derive a more precise estimation of these associations, we performed a meta-analysis to investigate the three main polymorphisms (SstI, T-455C, C-482T) of APOC3 in all published studies. Databases including PubMed, Web of Science, Wanfang, SinoMed and CNKI were systematically searched. The association was assessed using odds ratios (ORs) with 95% confidence intervals (CIs). The statistical analysis was performed using Review Manager 5.3.3 and Stata 12.0. A total of 31 studies have been identified. The pooled odds ratio (OR) for the association between the APOC3 gene polymorphisms and CHD and its corresponding 95% confidence interval (95% CI) were evaluated by random or fixed effect models. A statistical association between APOC3 SstI polymorphism and CHD susceptibility was observed under an allelic contrast model (P= 0.003, OR = 1.14, 95% CI = 1.05-1.24), dominant genetic model (P= 0.01, OR = 1.14, 95% CI = 1.03-1.26), and recessive genetic model (P= 0.02, OR = 1.35, 95% CI = 1.06-1.71), respectively. A significant association between the APOC3 T-455C polymorphism and CHD was also detected under an allelic contrast (P < 0.0001, OR = 1.19, 95% CI = 1.10-1.29), dominant genetic model (P= 0.0003, OR = 1.24, 95% CI = 1.11-1.39) and recessive genetic model (P= 0.04, OR = 1.30, 95% CI = 1.01-1.67). No significant association between the APOC3 C-482T polymorphism and CHD was found under an allelic model (P= 0.94, OR = 1.00, 95% CI = 0.93-1.08), dominant genetic model (P= 0.20, OR = 1.07, 95% CI = 0.97-1.18) or recessive genetic model (P= 0.13, OR = 0.90, 95% CI = 0.79-1.03). This meta-analysis revealed that the APOC3 SstI and T-455C polymorphisms significantly increase CHD susceptibility. No significant association was observed between the APOC3 C-482T polymorphism and CHD susceptibility.