The potential of gut microbiome as a non-invasive predictive biomarker for early detection of pancreatic cancer and hepatocellular carcinoma
The potential of gut microbiome as a non-invasive predictive biomarker for early detection of pancreatic cancer and hepatocellular carcinoma
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DOI：
10.26355/eurrev_202112_27421
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发表时间：
2021-01-01
影响因子：
3.3
通讯作者：
Bryl, E.
中科院分区：
文献类型：
--
作者：
Kazmierczak-Siedlecka, K.;Stachowska, E.;Bryl, E.
目的：探讨肠道微生物组作为胰腺癌和肝细胞癌早期检测的非侵入性预测生物标志物的潜力。材料和方法：我们分析了可获得的最新文献(PubMed, Embase。谷歌学者数据库)关于肠道微生物组与早期发现胰腺癌以及肝细胞癌之间的联系。使用了以下与肠道微生物组和上述癌症相关的搜索：“肠道微生物组”，“肠道微生物群”。“胰腺癌”、“胰腺导管腺癌”。肝细胞癌”。“微生物生物标志物”、“真菌菌群”、“真菌菌群”。搜索是用英语进行的。结果：近年来，肠道微生物群失衡与胰腺癌和肝细胞癌的发展之间的关系已被认识到。最常见的胰腺癌类型是胰腺导管腺癌，其癌变与口腔微生物生态失调、幽门螺杆菌感染、菌群、嗜肝病毒密切相关。以及胰腺内的微生物群。已知肠肝轴存在并可能影响肝癌的发生。目前，这些癌症的治疗策略非常有限，没有公认的筛查工具来早期诊断它们。人们越来越关注将肠道微生物组作为一种预测性的非侵入性生物标志物，用于早期检测胰腺癌和肝细胞癌。结论：总之，肠道微生物组作为一种非侵入性生物标志物与胰腺癌和肝细胞癌的早期检测之间存在联系，但尚未得到充分的研究。此外，许多研究都是在小样本量下进行的，而生物标志物依赖于种族，应该在更大范围的人群中进行验证。然而，这些方面是有希望的，并开辟了新的诊断选择。
OBJECTIVE: The aim of this paper was to discuss the potency of gut microbiome as a non-invasive predictive biomarker for early detection of pancreatic cancer and hepatocellular carcinoma.MATERIALS AND METHODS: We analysed the available up-to-date literature (PubMed, Embase. Google Scholar databases) regarding the link between gut microbiome and early detection of pancreatic cancer, as well as hepatocellular carcinoma. The following search linked to gut microbiome and aforementioned cancers was used: 'gut microbiome', 'gut microbiota'. 'pancreatic cancer', 'pancreatic ductal adenocarcinoma'. hepatocellular carcinoma'. 'microbial biomarkers', 'fungal microbiota', 'mycobiota'. The search was conducted in English.RESULTS: The association between gut microbiota imbalance and development of pancreatic cancer and hepatocellular carcinoma has been recognized during last several years. The most common type of pancreatic cancer is pancreatic ductal adenocarcinoma, whose carcinogenesis is strongly related to oral microbial dysbiosis, H. pylori infection, bactibilia, hepatotropic viruses. and intrapancreatic microbiota. It is known that gut-liver axis exists and may affect hepatocarcinogenesis. Currently, the treatment strategies of these cancers are strongly limited and there are not well-recognized screening tools to early diagnose them. The growing attention towards the use of gut microbiome as a predictive non-invasive biomarker to detect pancreatic cancer and hepatocellular carcinoma in early stage has been observed.CONCLUSIONS: To conclude, the field regarding the link between gut microbiome as a non-invasive biomarkers and early detection of pancreatic cancer and hepatocellular carcinoma exists, however, it is not well-investigated. Additionally, many of the studies were conducted with small sample sizes, whereas biomarkers are ethnicity-dependent and should be validated in wide range of populations. Nevertheless, these aspects are promising and open up new diagnostic options.