CD28-B7 interaction modulates short- and long-lived plasma cell function.
CD28-B7 interaction modulates short- and long-lived plasma cell function.
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DOI：
10.4049/jimmunol.1102728
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发表时间：
2012-09-15
期刊：
影响因子：
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通讯作者：
Jacob J
中科院分区：
文献类型：
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作者：
Njau MN;Kim JH;Chappell CP;Ravindran R;Thomas L;Pulendran B;Jacob J
T细胞上组成型表达的CD 28与APC上表达的B7.1/B7.2的相互作用对于T细胞活化至关重要。CD 28也在鼠和人浆细胞上表达，但其在这些细胞上的功能尚不清楚。有两种类型的浆细胞：在Ag暴露后不久出现在次级淋巴组织中的短寿命浆细胞，以及主要存在于骨髓中的长寿命浆细胞。我们证明，CD 28缺陷的小鼠短寿命和长寿命的浆细胞产生显着更高水平的抗体比野生型的同行。这是由于浆细胞的频率增加以及每个浆细胞的抗体产生增加。浆细胞还表达CD 28、B7.1和B7.2的配体。令人惊讶的是，B细胞中B7.1和B7.2的缺乏也导致了更高的Ab水平，类似于Cd 28 −/−浆细胞。总的来说，我们的研究结果表明，CD 28-B7相互作用作为浆细胞功能的关键调节剂。
The interaction of CD28, which is constitutively expressed on T cells, with B7.1/B7.2 expressed on APCs is critical for T cell activation. CD28 is also expressed on murine and human plasma cells but its function on these cells remains unclear. There are two types of plasma cells: short-lived ones that appear in the secondary lymphoid tissue shortly after Ag exposure, and long-lived plasma cells that mainly reside in the bone marrow. We demonstrate that CD28-deficient murine short- and long-lived plasma cells produce significantly higher levels of Abs than do their wild-type counterparts. This was owing to both increased frequencies of plasma cells as well as increased Ab production per plasma cell. Plasma cells also express the ligand for CD28, B7.1, and B7.2. Surprisingly, deficiency of B7.1 and B7.2 in B cells also led to higher Ab levels, analogous to Cd28−/− plasma cells. Collectively, our results suggest that the CD28–B7 interaction operates as a key modulator of plasma cell function.