Lifestyle Modification in Blood Pressure Study II (LIMBS): study protocol of a randomized controlled trial assessing the efficacy of a 24 week structured yoga program versus lifestyle modification on blood pressure reduction.
Lifestyle Modification in Blood Pressure Study II (LIMBS): study protocol of a randomized controlled trial assessing the efficacy of a 24 week structured yoga program versus lifestyle modification on blood pressure reduction.
复制标题
血压生活方式改变研究 II (LIMBS)：一项随机对照试验的研究方案，评估 24 周结构化瑜伽计划与生活方式改变对降低血压的功效。
DOI：
10.1016/j.cct.2013.05.010
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发表时间：
2013
影响因子：
2.2
通讯作者：
Townsend,RaymondR
中科院分区：
文献类型：
--
作者：
Cohen,DebbieL;Bowler,Anne;Fisher,StephenA;Norris,Angela;Newberg,Andrew;Rao,Hengyi;Bhavsar,Rupal;Detre,JohnA;Tenhave,Thomas;Townsend,RaymondR
高血压是一个主要的公共卫生问题，影响着美国6800万成年人。生活方式的改变包括补充疗法，如基于运动的心身瑜伽练习在美国越来越受欢迎，并被认为是一种潜在的降压药物替代方案。我们在2009年完成了一项试点研究，该研究显示，在12周的瑜伽锻炼后，24小时动态血压读数显著下降。基于我们试点研究的数据，我们现在正在完成生活方式调整和血压研究(肢体II)，这是一项2期随机对照试验，旨在确定瑜伽疗法和强化生活方式调整对高血压前期和1期高血压受试者降低血压的效果。肢体II使用24小时动态血压监测，旨在比较在24周内随机分组的受试者与以下三组之一的降压效果：瑜伽疗法与血压教育计划(限钠和步行计划)与涉及两组组件的组合计划。《肢体II》还将研究血压变化对脑血流的影响。如果成功，这项肢体研究将确定瑜伽疗法与强化的生活方式改变相结合是否会导致临床上有意义的血压下降，从而可以作为高血压前期和1期高血压患者药物治疗的替代方案。
Hypertension is a major public health issue affecting 68 million adults in the United States. Lifestyle modifications including complementary therapies such as the movement based mind body practice of yoga have become increasingly popular in the United States and have been considered as a potential alternative to medication in blood pressure reduction. We completed a pilot study in 2009 which showed meaningful decreases in 24-hour ambulatory blood pressure readings after a 12 week period of yoga participation. Based on data from our pilot study we are now completing The Lifestyle Modification and Blood Pressure Study (LIMBS II) which is a phase 2 randomized controlled trial designed to determine the effects of yoga therapy and enhanced lifestyle modification on lowering blood pressure in pre-hypertensive and stage 1 hypertensive subjects. Using 24-hour ambulatory blood pressure monitoring, LIMBS II aims to compare the effects on blood pressure reduction in subjects randomized for 24 weeks to one of the three following groups: yoga therapy versus blood pressure education program (sodium restriction and walking program) versus a combination program that involves components of both groups. LIMBS II will also examine the impact that changes in blood pressure have on cerebral blood flow. If successful, the LIMBS study will determine if yoga therapy combined with enhanced lifestyle modification will result in clinically meaningful decreases in blood pressure and thus can be implemented as an alternative to drug therapy for patients with prehypertension and stage 1 hypertension.