APOE genotype and age modifies the correlation between cognitive status and metabolites from hippocampus by a 2D (1)H-MRS in non-demented elders.
APOE genotype and age modifies the correlation between cognitive status and metabolites from hippocampus by a 2D (1)H-MRS in non-demented elders.
复制标题
通过 2D 1H-MRS 在非痴呆老年人中 APOE 基因型和年龄改变了认知状态和海马代谢物之间的相关性
作者：
Yin Z;Wu W;Liu R;Liang X;Yu T;Chen X;Feng J;Guo A;Xie Y;Yang H;Huang M;Tian C;Zhang B;Xu Y
目的。目的：研究年龄、载脂蛋白E(APOE)基因分型、2D 1H磁共振波谱(MRS)检测到的海马区代谢变化与非痴呆老年人认知神经心理指标之间的关系。材料和方法我们研究了年龄在66-88岁之间的16名认知正常对照(CN)和11名遗忘性轻度认知障碍(AMCI)患者的APOE基因多态性。在海马区测量了2D1H-MRS代谢物。在所有受试者中，根据年龄进行调整，通过Spearman偏序相关来衡量代谢变化和认知功能之间的关联。通过将受试者分为载脂蛋白Eε4携带者和非载脂蛋白ε4非携带者两组，评估载脂蛋白E状态的影响。结果。与年龄、性别和教育程度匹配的CN组相比，aMCI患者只在右侧海马区显示出肌醇(Mi)/肌酸(Cr)比值增加。双侧海马区N-乙酰天冬氨酸(NAA)/肌酸(NAA)/肌酸(mI/NAA)和肌酸/肌酸(mI/NAA)比值及左侧海马区肌酸/肌酸比值(mI/Cr)在两组间差异无统计学意义。非痴呆老年人右侧海马区mI/cr比值与蒙特利尔认知评估(MoCA)评分呈负相关。无论加入ε-4基因或年龄作为协变量，没有显著的相关性效应。此外，将年龄和载脂蛋白E基因一起调整后，它们之间没有显著的相关性。结论。由于aMCI患者右侧海马区的mi/cr高于CN患者，mI/cr可作为预测aMCI患者一般认知功能的更具特异性的指标。在非痴呆老年人中，右侧海马区较高的mI/cr与较差的认知功能之间存在关联，这种关联可以被APOE状态和年龄所修正。这为客观了解非痴呆老年人脑代谢产物与影响因素之间的机制提供了一个窗口。
Purpose. To examine the associations among age, Apolipoprotein E (APOE) genotype, metabolic changes in the hippocampus detected by 2D 1H magnetic resonance spectroscopy (MRS), and neuropsychological measures of cognition in non-demented elders. Materials and Methods. We studied a cohort of 16 cognitively normal controls (CN) and 11 amnestic mild cognitive impairment (aMCI) patients between 66 and 88 years old who were genotyped for APOE genetic polymorphism. Measurements of 2D1H-MRS metabolites were obtained in the hippocampus region. Adjusting by age among all subjects, the association between metabolic changes and cognitive function was measured by Spearman partial rank-order correlation. The effect of APOE status was measured by separating the subjects into APOE genotype subgroups, including the APOEε4 carriers and APOEε4 non-carriers. Results. In contrast to the CN group matched with age, gender, and education, aMCI patients showed increased myo-inositol (mI)/Creatine (Cr) ratio only in the right hippocampus. No differences were noted on N-acetylaspartate (NAA)/Cr and mI/NAA from bilateral hippocampus, and so was mI/Cr ratio in left hippocampus between aMCI and CN. The mI/Cr ratio from the right hippocampus in non-demented elders was negatively correlated with Montreal Cognitive Assessment (MoCA) scores. Whether ε4 genotype or age was added as a covariate, none of the correlation effects remained significant. Additionally, adjusting for age and APOE genotype together, there was no significant correlation between them. Conclusion. Since the higher mI/Cr from the right hippocampus of the patients with aMCI than those from CN, the mI/Cr could be a more specific predictor of general cognitive function in aMCI patients. There is an association between higher mI/Cr in right hippocampus and worse cognitive function for the non-demented older adults, and the correlation could be modified by APOE status and age. That provided a window on objectively understanding the mechanism between the brain metabolites and the influence factors in non-demented elders.