EFFECTS OF INTRANASAL ZINC-SULFATE ON OPEN-FIELD AND MATERNAL-BEHAVIOR IN FEMALE RATS
EFFECTS OF INTRANASAL ZINC-SULFATE ON OPEN-FIELD AND MATERNAL-BEHAVIOR IN FEMALE RATS
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DOI：
10.1016/0031-9384(77)90100-7
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发表时间：
1977-01-01
影响因子：
2.9
通讯作者：
ROSENBLATT, JS
中科院分区：
文献类型：
--
作者：
MAYER, AD;ROSENBLATT, JS
将未产白色大鼠鼻内（IN）或腹腔注射硫酸锌（Zn），或将盐水或空气注入IN，并在给药后24或48 h开始通过持续暴露幼仔诱导其表现出母性行为。ZnIN组和ZnIP组在旷场条件下的自发活动和直立能力均下降。ZnIN女性嗅闻更少，梳理更频繁，更多的总时间比ZnIP或空气女性，影响归因于鼻腔刺激和嗅觉受损。活性下降并没有出现由于全身吸收锌。母亲的行为诱导促进锌，但不是由ZnIP。IN注射程序的修改可能会减少意外吸入锌引起的治疗后虚弱。
Nulliparous white rats were injected intranasally (IN) or i.p. with ZnSO4 (Zn) or were injected IN with saline or air, and were induced to show maternal behavior through continuous pup exposure begun 24 or 48 h after treatment. ZnIN and ZnIP groups all showed declines in locomotor activity and rearing in an open field. ZnIN females sniffed less and groomed more often and for more total time than ZnIP or air females, effects attributed to nasal irritation and impaired olfaction. Declines in activity did not appear due to systemic absorption of Zn. Induction of maternal behavior was facilitated by ZnIN but not by ZnIP. Modifications of IN injection procedures probably reduced post-treatment debilitation caused by accidental aspiration of Zn.