Cilia and Mucociliary Clearance.
Cilia and Mucociliary Clearance.
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DOI：
10.1101/cshperspect.a028241
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发表时间：
2017-04-03
影响因子：
7.2
通讯作者：
Ostrowski LE
中科院分区：
文献类型：
--
作者：
Bustamante-Marin XM;Ostrowski LE
粘液纤毛清除（MCC）是肺的主要先天防御机制。其功能成分为保护性黏液层、气道表面液体层和纤毛细胞表面的纤毛。纤毛是一种特殊的细胞器，它在异向波中跳动，将被困在黏液层中的病原体和吸入颗粒赶出气道。在健康情况下，这种清除机制是有效的，但在原发性纤毛运动障碍（PCD）患者中，纤毛异常，导致MCC缺失和慢性肺部疾病。这表明纤毛对人类健康至关重要。在本章中，我们总结了MCC仪器组成的现有知识，重点是纤毛在MCC中的作用。
Mucociliary clearance (MCC) is the primary innate defense mechanism of the lung. The functional components are the protective mucous layer, the airway surface liquid layer, and the cilia on the surface of ciliated cells. The cilia are specialized organelles that beat in metachronal waves to propel pathogens and inhaled particles trapped in the mucous layer out of the airways. In health this clearance mechanism is effective, but in patients with primary cilia dyskinesia (PCD) the cilia are abnormal, resulting in deficient MCC and chronic lung disease. This demonstrates the critical importance of the cilia for human health. In this chapter we summarize the current knowledge of the components of the MCC apparatus, focusing on the role of cilia in MCC.