TUMOR-LOCALIZING ACTIVITY OF PORPHYRIN AND ITS AFFINITY TO LDL, TRANSFERRIN
TUMOR-LOCALIZING ACTIVITY OF PORPHYRIN AND ITS AFFINITY TO LDL, TRANSFERRIN
复制标题
DOI：
10.1016/0304-3835(95)03762-l
复制
发表时间：
1995-05-25
期刊：
影响因子：
9.7
通讯作者：
SAKATA, I
中科院分区：
文献类型：
--
作者：
NAKAJIMA, S;TAKEMURA, T;SAKATA, I
我们对12个具有不同疏水性的金属镓卟啉(Ga-CN-P)进行了光谱分析，观察到肿瘤中Ga-CN-P的体内定位与其与转铁蛋白和低密度脂蛋白的亲和力密切相关。~(99m)Tc-STA-R12显像剂对肿瘤的图像分析显示，静脉注射后约1h，STA-R12仅在肿瘤组织中定位。我们的结果表明，转铁蛋白和低密度脂蛋白介导的内吞作用的重要性，已被报道为卟啉定位肿瘤活性的机制之一。
We spectrochemically analyzed 12 Ga-Metal porphyrins (Ga-Cn-P) with different degrees of hydrophobicity, and observed a close association between the in vivo Ga-Cn-P localization in the tumor and its affinity to transferrin and LDL. Image analysis of tumors with 99m-Tc-STA-R12, a porphyrin-scintigraphic agent, revealed STA-R12 localization in the tumor tissue alone about 1 h after intravenous infusion. Our results suggest the importance of endocytosis mediated by transferrin as well as LDL that have been reported as a mechanism of the tumor-localizing activity of porphyrin.