How the body controls brain temperature: the temperature shielding effect of cerebral blood flow.
How the body controls brain temperature: the temperature shielding effect of cerebral blood flow.
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DOI：
10.1152/japplphysiol.00319.2006
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发表时间：
2006-11
影响因子：
3.3
通讯作者：
Mingming Zhu;J. Ackerman;A. Sukstanskii;D. Yablonskiy
中科院分区：
文献类型：
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作者：
Mingming Zhu;J. Ackerman;A. Sukstanskii;D. Yablonskiy
正常的大脑功能在很大程度上取决于保持大脑温度。然而，人们对保护大脑免受较冷环境影响的机制知之甚少。本文报道的是脑温度曲线的第一次详细测量。它被发现是指数，定义的特征温度屏蔽长度，与较冷的周边地区和温暖的大脑核心接近体温。直接脑血流量（CBF）的测量与微球表明，特征温度屏蔽长度与CBF的平方根成反比，与理论模型非常一致。这种“温度屏蔽效应”量化了CBF防止“颅外冷”穿透脑深部结构的手段。这种效应对于研究和临床应用至关重要;现在可以定量预测大脑，身体和颅外温度之间的关系。
Normal brain functioning largely depends on maintaining brain temperature. However, the mechanisms protecting brain against a cooler environment are poorly understood. Reported herein is the first detailed measurement of the brain-temperature profile. It is found to be exponential, defined by a characteristic temperature shielding length, with cooler peripheral areas and a warmer brain core approaching body temperature. Direct cerebral blood flow (CBF) measurements with microspheres show that the characteristic temperature shielding length is inversely proportional to the square root of CBF in excellent agreement with a theoretical model. This "temperature shielding effect" quantifies the means by which CBF prevents "extracranial cold" from penetrating deep brain structures. The effect is crucial for research and clinical applications; the relationship between brain, body, and extracranial temperatures can now be quantitatively predicted.