Angiogenesis and platelet-derived endothelial cell growth factor/thymidine phosphorylase expression in endometrial cancer.
Angiogenesis and platelet-derived endothelial cell growth factor/thymidine phosphorylase expression in endometrial cancer.
复制标题
子宫内膜癌中的血管生成和血小板源性内皮细胞生长因子/胸苷磷酸化酶的表达。
DOI：
10.3892/ijo.15.1.149
复制
发表时间：
1999
影响因子：
5.2
通讯作者：
T. Kudo
中科院分区：
文献类型：
--
作者：
N. Seki;J. Kodama;A. Hongo;Y. Miyagi;M. Yoshinouchi;T. Kudo
本研究的目的是阐明血管生成因子、血小板源性内皮细胞生长因子（PD-ECGF）/胸苷磷酸化酶（dThdR）与子宫内膜癌的临床病理因素（包括肿瘤血管生成和患者预后）之间的关系。PD-ECGF在癌细胞中的表达与任何临床病理变量之间均无相关性。间质细胞PD-ECGF的免疫阳性率在低分化腺癌中显著较高。微血管计数与PD-ECGF阳性基质细胞相关（p<0.0001）。间质细胞PD-ECGF表达显著和微血管计数高的患者无病生存率显著更差。采用考克斯比例风险模型的多变量分析显示，高微血管计数独立预测无病生存率以及分期和子宫肌层浸润。间质细胞表达PD-ECGF可能在促进血管生成中起重要作用。肿瘤血管生成可用于预测子宫内膜癌患者的预后。
The object of this study was to clarify the association of angiogenic factor, platelet-derived endothelial cell growth factor (PD-ECGF)/thymidine phosphorylase (dThdPase) with clinicopathological factors including tumor angiogenesis and patient outcome in endometrial cancer. There was no correlation between the expression of PD-ECGF in cancer cells and any of the clinicopathological variables. Immunopositivity for PD-ECGF in stroma cells was significantly higher in poorly differentiated adenocarcinomas. The microvessel counts correlated with PD-ECGF positive stroma cells (p<0.0001). Disease-free survival was significantly worse in patients with marked PD-ECGF expression in stromal cells and high microvessel count. A multivariate analysis using Cox's proportional hazard model showed that high microvessel counts independently predicted disease-free survival as well as stage and myometrial invasion. The expression of PD-ECGF in stroma cells may play a crucial role in the promotion of angiogenesis. Tumor angiogenesis can be used to predict prognosis in patients with endometrial cancer.