Visceral hypersensitivity: facts, speculations, and challenges
Visceral hypersensitivity: facts, speculations, and challenges
复制标题
DOI：
10.1136/gut.48.1.125
复制
发表时间：
2001-01-01
期刊：
影响因子：
24.5
通讯作者：
Tack, JF
中科院分区：
文献类型：
--
作者：
Camilleri, M;Coulie, B;Tack, JF
内脏过敏是目前的圣杯……它被广泛认为是功能性胃肠道疾病发展的原因，包括功能性消化不良和肠易激综合征。1尽管这一领域在过去十年中取得了长足的进步，但有必要总结和现实地评估我们目前的理解。查明有争议的问题将有助于解决今后推动这一领域的方向或优先事项。因此，我们的目标是回顾目前对肠道感觉的神经解剖学和生理学的理解，简要回顾症状和感觉运动障碍之间的关系的例子，并讨论需要更深入研究的争议和推测。在进行这一讨论时，我们借鉴了本组织几个区域的经验和数据，因为单一区域的工作不能提供必要的全面或广泛的观点。
Visceral hypersensitivity is currently the holy grail.... it is widely regarded as the reason for the development of functional gastrointestinal diseases, including functional dyspepsia and irritable bowel syndrome. 1 Although the field has advanced considerably in the past decade, it is necessary to take stock and realistically appraise our current understanding. Identifying issues of controversy will help address the directions or priorities to advance this field in the future. Thus our objectives are to review the current understanding of the neuroanatomy and physiology of gut sensation, briefly review examples of the relationship between symptoms and sensorimotor dysfunction, and discuss controversies and speculations requiring more thorough study. In pursuing this discussion, we have drawn on experience and data from several regions of the gut as work in a single region does not provide the comprehensive or broad perspectives necessary.