Muscle Sympathetic Nerve Activity Is Associated with Liver Insulin Sensitivity in Obese Non-Diabetic Men.
Muscle Sympathetic Nerve Activity Is Associated with Liver Insulin Sensitivity in Obese Non-Diabetic Men.
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肥胖非糖尿病男性的肌肉交感神经活动与肝脏胰岛素敏感性相关。
DOI：
10.3389/fphys.2017.00101
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发表时间：
2017
影响因子：
4
通讯作者：
Greenfield JR
中科院分区：
文献类型：
--
作者：
Chen DL;Brown R;Liess C;Poljak A;Xu A;Zhang J;Trenell M;Jenkins A;Chisholm D;Samocha-Bonet D;Macefield VG;Greenfield JR
简介：肌肉交感神经活动 (MSNA) 可能在肥胖的胰岛素抵抗中发挥作用。然而，MSNA 与肥胖中胰岛素抵抗之间关系的方向和性质仍不清楚。我们假设静息 MSNA 与肌肉和肝脏胰岛素敏感性呈负相关，并且胰岛素抵抗受试者的静息 MSNA 高于胰岛素敏感受试者。材料和方法：对 45 名非糖尿病肥胖受试者进行了研究。由于在女性中没有发现显着的关系，因此数据以 22 名年龄 48 ± 12 岁的男性为对象。使用氘代葡萄糖进行两步（15 和 80 mU/m2/min）高胰岛素-正常血糖钳夹以确定肝脏和肌肉的胰岛素敏感性。评估临床和代谢参数。 MSNA 通过经皮插入腓总神经的微电极进行测量。结果：MSNA 突发频率与肝脏胰岛素敏感性呈负相关（r = -0.53，P = 0.02），与肝因子 C 反应蛋白（CRP）和成纤维细胞生长因子（FGF）-19 呈正相关（分别为 r = 0.57，P = 0.006 和 r = -0.47，P = 0.03）。与利弗雷斯相比，利弗森的 MSNA 突发频率较低（每分钟 27 ± 5 次与 38 ± 2 次突发；P = 0.03）。肌肉胰岛素敏感性与 MSNA 无关。讨论：非糖尿病肥胖男性的交感神经激活与肝脏胰岛素敏感性以及循环肝因子 CRP 和 FGF-19 有关。这些结果表明潜在的肝内分泌自主神经轴。未来的研究需要阐明 MSNA 对男性肝脏胰岛素敏感性的影响。
Introduction: Muscle sympathetic nerve activity (MSNA) may play a role in insulin resistance in obesity. However, the direction and nature of the relationship between MSNA and insulin resistance in obesity remain unclear. We hypothesized that resting MSNA would correlate inversely with both muscle and liver insulin sensitivity and that it would be higher in insulin-resistant vs. insulin-sensitive subjects. Materials and methods: Forty-five non-diabetic obese subjects were studied. As no significant relationships were found in women, the data presented in on 22 men aged 48 ± 12 years. Two-step (15 and 80 mU/m2/min) hyperinsulinaemic-euglycaemic clamps were performed using deuterated glucose to determine liver and muscle insulin sensitivity. Clinical and metabolic parameters were assessed. MSNA was measured via a microelectrode inserted percutaneously into the common peroneal nerve. Results: MSNA burst frequency correlated inversely with liver insulin sensitivity (r = −0.53, P = 0.02) and positively with the hepatokines C-reactive protein (CRP) and fibroblast growth factor (FGF)-19 (r = 0.57, P = 0.006, and r = −0.47, P = 0.03, respectively). MSNA burst frequency was lower in Liversen compared to Liverres (27 ± 5 vs. 38 ± 2 bursts per minute; P = 0.03). Muscle insulin sensitivity was unrelated to MSNA. Discussion: Sympathetic neural activation is related to liver insulin sensitivity and circulating hepatokines CRP and FGF-19 in non-diabetic obese men. These results suggest a potential hepato-endocrine-autonomic axis. Future studies are needed to clarify the influence of MSNA on liver insulin sensitivity in men.