Males lose hearing earlier in mouse models of late-onset age-related hearing loss; females lose hearing earlier in mouse models of early-onset hearing loss
Males lose hearing earlier in mouse models of late-onset age-related hearing loss; females lose hearing earlier in mouse models of early-onset hearing loss
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DOI：
10.1016/s0378-5955(03)00401-5
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发表时间：
2004-04-01
期刊：
影响因子：
2.8
通讯作者：
Henry, KR
中科院分区：
文献类型：
--
作者：
Henry, KR
人类听力的性别差异归因于遗传、环境和/或遗传X环境的相互作用因素。这些差异随着年龄的增长而增加，男性表现出更高的高频阈值。适当的动物模型可以帮助预测、治疗和预防其中的一些损失。本文研究了被广泛用作晚期（CBA/J和CBA/CaJ）和早期（C57BL/6J）发病年龄相关性听力损失模型的近交系小鼠。在前两种基因型中，男性的听觉脑干反应（ABR）高频刺激阈值高于女性。这种性别差异在CBA/CaJ的耳蜗神经包膜反应阈值上不太明显，尽管这种反应对年龄的影响比ABR更敏感。相比之下，男性C57BL/6J的敏感阈值高于女性，随着年龄的增长，两项指标的敏感性都大幅下降。这些数据在这些动物作为工具的适用性方面进行了讨论，以检查降低耳蜗功能的因素。(C) 2004 Elsevier B.V.版权所有
Gender-related differences in human hearing have been attributed to genetic, environmental, and/or genetic X environmental interactive factors. These differences tend to increase with age, with males showing greater high frequency threshold elevations. An appropriate animal model could aid in prediction, treatment, and prevention of some of these losses. This paper examines inbred strains of mice that are widely used as models of late- (CBA/J and CBA/CaJ) and early- (C57BL/6J) onset age-related hearing loss. In the former two genotypes, the thresholds to high frequency stimuli of the auditory brainstem response (ABR) are higher in the male than in the female. This gender difference was less pronounced in thresholds to the cochlear nerve envelope response of the CBA/CaJ, although this response was more sensitive to the influence of age than was the ABR. In contrast, the male C57BL/6J had more sensitive thresholds than the female, with both measures showing massive loss of sensitivity with increasing age. The data are discussed in terms of the applicability of these animals as tools for examining factors that degrade cochlear function. (C) 2004 Elsevier B.V. All rights reserved.