Interactions of Cannabinoids With Biochemical Substrates.
Interactions of Cannabinoids With Biochemical Substrates.
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DOI：
10.1177/1178221817711418
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Thomas BF
中科院分区：
文献类型：
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作者：
Thomas BF
近几十年来，在大麻素受体的鉴定和表征以及大麻植物衍生物与受体结合并产生其生理和心理效应的机制的阐明方面取得了很大进展。在这一过程中产生的信息使人们能够更好地了解由中枢和外周神经系统控制的基本生理和心理过程，并促进了天然和合成大麻素作为治疗剂的开发。这一长达数十年的努力的一个消极方面是秘密合成的类似物作为具有危险影响的娱乐性街头毒品的扩散。目前，大麻素与其生化底物的相互作用被广泛但不充分地理解，衍生和合成的受体配体的临床应用仍然非常有限。大麻素系统的广泛解剖分布和功能复杂性继续表明治疗和副作用的潜力，这为参与药物发现和开发的药物化学家提供了挑战和机遇。
Recent decades have seen much progress in the identification and characterization of cannabinoid receptors and the elucidation of the mechanisms by which derivatives of the Cannabis sativa plant bind to receptors and produce their physiological and psychological effects. The information generated in this process has enabled better understanding of the fundamental physiological and psychological processes controlled by the central and peripheral nervous systems and has fostered the development of natural and synthetic cannabinoids as therapeutic agents. A negative aspect of this decades-long effort is the proliferation of clandestinely synthesized analogs as recreational street drugs with dangerous effects. Currently, the interactions of cannabinoids with their biochemical substrates are extensively but inadequately understood, and the clinical application of derived and synthetic receptor ligands remains quite limited. The wide anatomical distribution and functional complexity of the cannabinoid system continue to indicate potential for both therapeutic and side effects, which offers challenges and opportunities for medicinal chemists involved in drug discovery and development.