Enantioselective construction of spiroindolenines by Ir-catalyzed allylic alkylation reactions.
Enantioselective construction of spiroindolenines by Ir-catalyzed allylic alkylation reactions.
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DOI：
10.1021/ja105111n
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发表时间：
2010-08
影响因子：
15
通讯作者：
Qing-Feng Wu;H. He;Wen-Bo Liu;S. You
中科院分区：
文献类型：
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作者：
Qing-Feng Wu;H. He;Wen-Bo Liu;S. You
以2-甲基-1，2，3，4-四氢喹啉衍生的亚磷酰胺配体（R，R（a））-L（6）为催化剂，实现了吲哚的分子内C-3烯丙基烷基化反应，得到了高对映体富集的螺吲哚啉衍生物，产率为92-98%，dr>99/1，ee> 97%.
With 2-methyl-1,2,3,4-tetrahydroquinoline-derived phosphoramidite ligand (R,R(a))-L(6), Ir-catalyzed intramolecular C-3 allylic alkylation of indoles has been realized to afford highly enantioenriched spiroindolenine derivatives in 92-98% yields with up to >99/1 dr and 97% ee.